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Near-infrared autofluorescence induced by intraplaque hemorrhage and heme degradation as marker for high-risk atherosclerotic plaques
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Htun, Nay Min, Chen, Yung Chih, Lim, Bock, Schiller, Tara L., Maghzal, Ghassan J, Huang, Alex L., Elgass, Kirstin D., Rivera, Jennifer, Schneider, Hans G., Wood, Bayden R., Stocker, Roland and Peter, Karlheinz (2017) Near-infrared autofluorescence induced by intraplaque hemorrhage and heme degradation as marker for high-risk atherosclerotic plaques. Nature Communications, 8 (1). 75. doi:10.1038/s41467-017-00138-x
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Official URL: http://doi.org/10.1038/s41467-017-00138-x
Abstract
Atherosclerosis is a major cause of mortality and morbidity, which is mainly driven by complications such as myocardial infarction and stroke. These complications are caused by thrombotic arterial occlusion localized at the site of high-risk atherosclerotic plaques, of which early detection and therapeutic stabilization are urgently needed. Here we show that near-infrared autofluorescence is associated with the presence of intraplaque hemorrhage and heme degradation products, particularly bilirubin by using our recently created mouse model, which uniquely reflects plaque instability as seen in humans, and human carotid endarterectomy samples. Fluorescence emission computed tomography detecting near-infrared autofluorescence allows in vivo monitoring of intraplaque hemorrhage, establishing a preclinical technology to assess and monitor plaque instability and thereby test potential plaque-stabilizing drugs. We suggest that near-infrared autofluorescence imaging is a novel technology that allows identification of atherosclerotic plaques with intraplaque hemorrhage and ultimately holds promise for detection of high-risk plaques in patients.
| Item Type: | Journal Article | ||||||||||||
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| Subjects: | R Medicine > RC Internal medicine | ||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) | ||||||||||||
| SWORD Depositor: | Library Publications Router | ||||||||||||
| Library of Congress Subject Headings (LCSH): | Atherosclerosis -- Risk factors, Atherosclerotic plaque -- Imaging, Tomography, Emission, Fluorescence spectroscopy | ||||||||||||
| Journal or Publication Title: | Nature Communications | ||||||||||||
| Publisher: | Nature Publishing Group | ||||||||||||
| ISSN: | 2041-1723 | ||||||||||||
| Official Date: | 13 July 2017 | ||||||||||||
| Dates: |
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| Volume: | 8 | ||||||||||||
| Number: | 1 | ||||||||||||
| Number of Pages: | 16 | ||||||||||||
| Article Number: | 75 | ||||||||||||
| DOI: | 10.1038/s41467-017-00138-x | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | Published | ||||||||||||
| Reuse Statement (publisher, data, author rights): | ** From PubMed via Jisc Publications Router. ** History: ** received: 28-03-2016 ** accepted: 02-06-2017 | ||||||||||||
| Access rights to Published version: | Open Access | ||||||||||||
| Funder: | National Health and Medical Research Council (Australia) (NHMRC) | ||||||||||||
| Grant number: | 1003234, 1056569, 1080604 | ||||||||||||
| RIOXX Funder/Project Grant: |
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