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Evaluation of a measles vaccine campaign by oral-fluid surveys in a rural Kenyan district: interpretation of antibody prevalence data using mixture models

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Ohuma, E. O., Okiro, E. A., Bett, A., Abwao, John, Were, S., Samuel, Dhan, Vyse, A. J., Gay, N. J., Brown, D. W. G. and Nokes, D. James. (2009) Evaluation of a measles vaccine campaign by oral-fluid surveys in a rural Kenyan district: interpretation of antibody prevalence data using mixture models. Epidemiology and Infection, Vol.13 (No.2). pp. 227-233. ISSN 0950-2688

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Official URL: http://dx.doi.org/10.1017/S0950268808000848

Abstract

We evaluated the effectiveness of a measles vaccine campaign in rural Kenya, based on oral-fluid surveys and mixture-modelling analysis. Specimens were collected from 886 children aged 9 months to 14 years pre-campaign and from a comparison sample of 598 children aged 6 months post-campaign. Quantitative measles-specific antibody data were obtained by commercial kit. The estimated proportions of measles-specific antibody negative in children aged 0–4, 5–9 and 10–14 years were 51%, 42% and 27%, respectively, pre- campaign and 18%, 14% and 6%, respectively, post-campaign. We estimate a reduction in the proportion susceptible of 65–78%, with ~85% of the population recorded to have received vaccine. The proportion of ‘weak’ positive individuals rose from 35% pre-campaign to 54% post-campaign. Our results confirm the effectiveness of the campaign in reducing susceptibility to measles and demonstrate the potential of oral-fluid studies to monitor the impact of measles vaccination campaigns.

Item Type:	Journal Article
Subjects:	R Medicine > RA Public aspects of medicine
Divisions:	Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)
Library of Congress Subject Headings (LCSH):	Vaccination of children -- Kenya, Communicable diseases -- Prevention, Measles -- Vaccination -- Kenya, Immunoglobulins
Journal or Publication Title:	Epidemiology and Infection
Publisher:	Cambridge University Press
ISSN:	0950-2688
Date:	February 2009
Volume:	Vol.13
Number:	No.2
Page Range:	pp. 227-233
Identification Number:	10.1017/S0950268808000848
Status:	Peer Reviewed
Access rights to Published version:	Open Access
Funder:	Wellcome Trust (London, England)
Grant number:	061584 (Wellcome)
References:	1. Gay, NJ, et al. Improving sensitivity of oral fluid testing in IgG prevalence studies: application of mixture models to a rubella antibody survey. Epidemiology and Infection 2003; 130: 285–291. 2. Vyse, AJ, Cohen, BJ, Ramsay, ME. A comparison of oral fluid collection devices for use in the surveillance of virus diseases in children. Public Health 2001; 115: 201–207. 3. Nokes, DJ, et al. Has oral fluid the potential to replace serum for the evaluation of population immunity levels? A study of measles, rubella and hepatitis B in rural Ethiopia. Bulletin of the World Health Organization 2001; 79: 588–595. 4. Nokes, DJ, et al. An evaluation of oral-fluid collection devices for the determination of rubella antibody status in a rural Ethiopian community. Transactions of the Royal Socity of Tropical Medicine and Hygiene 1998; 92: 679–685. 5. Nokes, DJ, et al. A comparison of oral fluid and serum for the detection of rubella-specific antibodies in a community study in Addis Ababa, Ethiopia. Tropical Medicine & International Health 1998; 3: 258–267. 6. Vyse, AJ, et al. Detection of antibody to Epstein–Barr virus viral capsid antigen in saliva by antibody capture radioimmunoassay. Journal of Virological Methods 1997; 63: 93–101. 7. Vyse, AJ, et al. Detection of rubella virus-specific immunoglobulin G in saliva by an amplification-based enzyme-linked immunosorbent assay using monoclonal antibody to fluorescein isothiocyanate. Journal of Clinical Microbiology 1999; 37: 391–395. 8. Vyse, AJ, et al. Interpreting serological surveys using mixture models: the seroepidemiology of measles, mumps and rubella in England and Wales at the beginning of the 21st century. Epidemiology and Infection 2006; 134: 1303–1312. 9. Nigatu, W, et al. Detection of measles specific IgG in oral fluid using an FITC/anti-FITC IgG capture enzyme linked immunosorbent assay (GACELISA). Journal of Virological Methods 1999; 83: 135–44. 10. Hesketh, L, et al. An evaluation of nine commercial EIA kits for the detection of measles specific IgG. Journal of Virological Methods 1997; 66: 51–59. 11. Kremer, JR, Muller, CP. Evaluation of commercial assay detecting specific immunoglobulin g in oral fluid for determining measles immunity in vaccinees. Clinical and Diagnostic Laboratory Immunology 2005; 12: 668–670. 12. Mossong, J, et al. Modeling the impact of subclinical measles transmission in vaccinated populations with waning immunity. American Journal of Epidemiology 1999; 150: 1238–1249. 13. CDC. Progress in measles control – Kenya 2002–2007. Morbidity and Mortality Weekly Report 2007; 56: 969–972. 14. Kenya National Bureau of Statistics. Population distribution by province/district and sex: 1979–1999 Censuses, 1999. 15. Cutts, FT, et al. Prevalence of measles antibody among children under 15 years of age in Santa Cruz, Bolivia: implications for vaccination strategies. Transactions of the Royal Socity of Tropical Medicine and Hygiene 1995; 89: 119–122. 16. Cox, MJ, et al. Measles antibody levels in a vaccinated population in Brazil. Transactions of the Royal Socity of Tropical Medicine and Hygiene 1998; 92: 227–230. 17. Enquselassie, F, et al. Seroepidemiology of measles in Addis Ababa, Ethiopia: implications for control through vaccination. Epidemiology and Infection 2003; 130: 507–519. 18. WHO. Vaccine Preventable Disease unit of WHO/African Region, Vaccine Preventable Diseases Bulletin WHO/AFRO. AFRO EPI-Newsletter, October, 2001(016). 19. WHO. Report on the 1st Consultation of the Technical Advisory Group on Measles and Rubella Control in the African Region. Harare, Zimbabwe: World Health Organisation Regional Office for Africa, 2005. 20. CDC. Effects of measles-control activities – African region, 1999–2005. Morbidity and Mortality Weekly Report 2006; 55: 1017–1021.
URI:	http://wrap.warwick.ac.uk/id/eprint/905