Inferring the diameter of a biopolymer from its stretching response
Toan, Ngo Minh, Marenduzzo, Davide and Micheletti, C. (Cristian). (2005) Inferring the diameter of a biopolymer from its stretching response. Biophysical Journal, Vol.89 (No.1). pp. 80-86. ISSN 0006-3495
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Official URL: http://dx.doi.org/10.1529/biophysj.104.058081
We investigate the stretching response of a thick polymer model by means of extensive stochastic simulations. The computational results are synthesized in an analytic expression that characterizes how the force versus elongation curve depends on the polymer structural parameters: its thickness and granularity (spacing of the monomers). The expression is used to analyze experimental data for the stretching of various different types of biopolymers: polypeptides, polysaccharides, and nucleic acids. Besides recovering elastic parameters (such as the persistence length) that are consistent with those obtained from standard entropic models, the approach allows us to extract viable estimates for the polymers diameter and granularity. This shows that the basic structural polymer features have such a profound impact on the elastic behavior that they can be recovered with the sole input of stretching measurements.
|Item Type:||Journal Article|
|Subjects:||Q Science > QP Physiology|
|Divisions:||Faculty of Science > Mathematics|
|Library of Congress Subject Headings (LCSH):||Biopolymers, Polymers -- Surfaces, Polymers -- Mathematical models|
|Journal or Publication Title:||Biophysical Journal|
|Official Date:||July 2005|
|Page Range:||pp. 80-86|
|Access rights to Published version:||Open Access|
|Funder:||Istituto Nazionale Fisica della Materia (INFM)|
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