Sens, Pierre and Turner, Matthew S. (2004) Theoretical model for the formation of caveolae and similar membrane invaginations. Biophysical Journal, Vol.86 (No.4). pp. 2049-2057. doi:10.1016/S0006-3495(04)74266-6

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Abstract

We study a physical model for the formation of bud-like invaginations on fluid lipid membranes under tension, and apply this model to caveolae formation. We demonstrate that budding can be driven by membrane-bound proteins, provided that they exert asymmetric forces on the membrane that give rise to bending moments. In particular, caveolae formation does not necessarily require forces to be applied by the cytoskeleton. Our theoretical model is able to explain several features observed experimentally in caveolae, where proteins in the caveolin family are known to play a crucial role in the formation of caveolae buds. These include 1), the formation of caveolae buds with sizes in the 100-nm range and 2), that certain N- and C-termini deletion mutants result in vesicles that are an order-of-magnitude larger. Finally, we discuss the possible origin of the morphological striations that are observed on the surfaces of the caveolae.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology
Divisions:	Faculty of Science > Physics
Library of Congress Subject Headings (LCSH):	Cell membranes -- Formation, Cell receptors, Proteins, Lipid membranes
Journal or Publication Title:	Biophysical Journal
Publisher:	Biophysical Society
ISSN:	0006-3495
Official Date:	April 2004
Dates:	Date Event April 2004 Published
Volume:	Vol.86
Number:	No.4
Page Range:	pp. 2049-2057
DOI:	10.1016/S0006-3495(04)74266-6
Status:	Peer Reviewed
Access rights to Published version:	Open Access
Funder:	Royal Society (Great Britain)

Data sourced from Thomson Reuters' Web of Knowledge

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