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Targeted treatment of yaws with contact tracing : how much do we miss?
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Dyson, Louise, Marks, Michael, Crook, Oliver M., Sokana, Oliver, Solomon, Anthony W., Bishop, Alex, Mabey, David C. W. and Hollingsworth, T. Déirdre (2018) Targeted treatment of yaws with contact tracing : how much do we miss? American Journal of Epidemiology, 184 (4). pp. 837-844. doi:10.1093/aje/kwx305 ISSN 0002-9262.
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Official URL: https://doi.org/10.1093/aje/kwx305
Abstract
Yaws is a disabling bacterial infection found primarily in warm and humid tropical areas. The World Health Organization strategy mandates an initial round of total community treatment (TCT) with single-dose azithromycin followed either by further TCT or active case-finding and treatment of cases and their contacts (the Morges strategy). We sought to investigate the effectiveness of the Morges strategy. We employed a stochastic household model to study the transmission of infection using data collected from a pre-TCT survey conducted in the Solomon Islands. We used this model to assess the proportion of asymptomatic infections that occurred in households without active cases. This analysis indicated that targeted treatment of cases and their household contacts would miss a large fraction of asymptomatic infections (65%–100%). This fraction was actually higher at lower prevalences. Even assuming that all active cases and their households were successfully treated, our analysis demonstrated that at all prevalences present in the data set, up to 90% of (active and asymptomatic) infections would not be treated under household-based contact tracing. Mapping was undertaken as part of the study “Epidemiology of Yaws in the Solomon Islands and the Impact of a Trachoma Control Programme,” in September–October 2013.
| Item Type: | Journal Article | ||||||||||||||||||||||||
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| Subjects: | R Medicine > RC Internal medicine | ||||||||||||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Science > Mathematics |
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| Library of Congress Subject Headings (LCSH): | Yaws., Yaws -- Prevention., Syphilis. | ||||||||||||||||||||||||
| Journal or Publication Title: | American Journal of Epidemiology | ||||||||||||||||||||||||
| Publisher: | Oxford University Press | ||||||||||||||||||||||||
| ISSN: | 0002-9262 | ||||||||||||||||||||||||
| Official Date: | 1 April 2018 | ||||||||||||||||||||||||
| Dates: |
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| Volume: | 184 | ||||||||||||||||||||||||
| Number: | 4 | ||||||||||||||||||||||||
| Page Range: | pp. 837-844 | ||||||||||||||||||||||||
| DOI: | 10.1093/aje/kwx305 | ||||||||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||||||||
| Date of first compliant deposit: | 10 August 2017 | ||||||||||||||||||||||||
| Date of first compliant Open Access: | 6 March 2018 | ||||||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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