The Library
Faecal calprotectin for differentiating between irritable bowel syndrome and inflammatory bowel disease : a useful screen in daily gastroenterology practice
Tools
Tools
Tools
Banerjee, Ashwini, Srinivas, M., Eyre, Richard, Ellis, Robert, Waugh, Norman, Bardhan, Karna Dev and Basumani, P. (2015) Faecal calprotectin for differentiating between irritable bowel syndrome and inflammatory bowel disease : a useful screen in daily gastroenterology practice. Frontline Gastroenterology, 6 (1). pp. 20-26. doi:10.1136/flgastro-2013-100429
Research output not available from this repository, contact author.
Official URL: http://dx.doi.org/10.1136/flgastro-2013-100429
Abstract
Objective To determine the best faecal calprotectin (FCP) cut-off level for differentiating between irritable bowel syndrome (IBS) and organic disease, particularly inflammatory bowel disease (IBD), in patients presenting with chronic diarrhoea.
Design Retrospective analysis of patients who had colonoscopy, histology and FCP completed within 2 months.
Setting District general hospital.
Patients Consecutive new patients with chronic diarrhoea lasting longer than 4 weeks.
Interventions Patients were seen by a single experienced gastroenterologist and listed for colonoscopy with histology. Laboratory investigations included a single faecal specimen for calprotectin assay (lower limit of detection: 8 µg/g), the results used for information only.
Main outcome measures Six FCP cut-off levels (range 8–150 µg/g) were compared against the ‘gold standard’ of histology: inflammation ‘present’ or ‘absent’.
Results Of 119 patients studied, 98 had normal colonoscopy and histology. The sensitivity of FCP to detect IBD at cut-off levels 8, 25 and 50 µg/g was 100% (with corresponding specificity 51%, 51%, 60%). In contrast, the lowest FCP cut-off, 8 µg/g, had 100% sensitivity to detect colonic inflammation, irrespective of cause (with negative predictive value (NPV) 100%). Importantly, 50/119 patients (42%) with FCP <8 µg/g had normal colonoscopy and histology.
Conclusions Our results suggest that using FCP to screen patients newly referred for chronic diarrhoea could exclude all without IBD and, at a lower cut-off, all without colonic inflammation, thus avoiding the need for colonoscopy. Such a major reduction has implications for resource allocation.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School |
||||||||
| Journal or Publication Title: | Frontline Gastroenterology | ||||||||
| Publisher: | BMJ Group | ||||||||
| ISSN: | 2041-4137 | ||||||||
| Official Date: | January 2015 | ||||||||
| Dates: |
|
||||||||
| Volume: | 6 | ||||||||
| Number: | 1 | ||||||||
| Page Range: | pp. 20-26 | ||||||||
| DOI: | 10.1136/flgastro-2013-100429 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
