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Detecting signatures of past pathogen selection on human HLA loci : are there needles in the haystack?
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Penman, Bridget S. and Gupta, Sunetra (2018) Detecting signatures of past pathogen selection on human HLA loci : are there needles in the haystack? Parasitology , 145 (6). pp. 731-739. doi:10.1017/S0031182017001159
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Official URL: http://dx.doi.org/10.1017/S0031182017001159
Abstract
Human Leukocyte Antigens (HLAs) are responsible for the display of peptide fragments for recognition by T cell receptors. The gene family encoding them is thus integral to human adaptive immunity, and likely to be under strong pathogen selection. Despite this, it has proved difficult to demonstrate specific examples of pathogen-HLA coevolution. Selection from multiple pathogens simultaneously could explain why the evolutionary signatures of particular pathogens on HLAs have proved elusive. Here, we present an individual-based model of HLA evolution in the presence of two mortality-causing pathogens. We demonstrate that it is likely that individual pathogen species causing high mortality have left recognizable signatures on the HLA genomic region, despite more than one pathogen being present. Such signatures are likely to exist at the whole-population level, and involve haplotypic combinations of HLA genes rather than single loci.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QR Microbiology | ||||||||
| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||||
| Library of Congress Subject Headings (LCSH): | HLA histocompatibility antigens, Host-parasite relationships, Evolutionary genetics, Immunogenetics | ||||||||
| Journal or Publication Title: | Parasitology | ||||||||
| Publisher: | Cambridge University Press | ||||||||
| ISSN: | 0031-1820 | ||||||||
| Official Date: | May 2018 | ||||||||
| Dates: |
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| Date of first compliant deposit: | 18 August 2017 | ||||||||
| Volume: | 145 | ||||||||
| Number: | 6 | ||||||||
| Page Range: | pp. 731-739 | ||||||||
| DOI: | 10.1017/S0031182017001159 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Funder: | Seventh Framework Programme (European Commission) (FP7) | ||||||||
| Grant number: | 268904 (FP7) |
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