Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Ultralow dispersity poly(vinyl alcohol) reveals significant dispersity effects on ice recrystallization inhibition activity

Tools
- Tools
+ Tools

Vial, N., Stubbs, Christopher D., Biggs, Caroline I. and Gibson, Matthew I. (2017) Ultralow dispersity poly(vinyl alcohol) reveals significant dispersity effects on ice recrystallization inhibition activity. ACS Macro Letters, 6 (9). pp. 1001-1004. doi:10.1021/acsmacrolett.7b00595

[img]
Preview
PDF
WRAP-ultralow-dispersity-poly-vinyl-alcohol-Gibson-2017.pdf - Accepted Version - Requires a PDF viewer.

Download (1703Kb) | Preview
[img]
Preview
PDF
WRAP-supplementary-material.pdf - Supplemental Material - Requires a PDF viewer.

Download (486Kb) | Preview
Official URL: http://dx.doi.org/10.1021/acsmacrolett.7b00595

Request Changes to record.

Abstract

Polymer mimics of antifreeze proteins are emerging as an exciting class of macromolecular cryoprotectants for the storage of donor cells and tissue. Poly(vinyl alcohol), PVA, is the most potent polymeric ice growth inhibitor known, but its mode of action and the impact of valency (DP) are not fully understood. Herein, tandem RAFT polymerization and column chromatography are used to isolate oligomers with dispersities <1.01 to enable the effect of molecular weight distribution, as well as length, to be probed. It is found that polymers with equal number average molecular weight, but lower dispersity, have significantly less activity, which can lead to false positives when identifying structure-property relationships. The minimum chain length for PVA’s unique activity, compared to other non-active poly-ols was identified. These results will guide the design of more active inhibitors, better cryopreservatives and a deeper understanding of synthetic and biological antifreeze macromolecules.

Item Type: Journal Article
Subjects: Q Science > QH Natural history
Divisions: Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH): Antifreeze proteins, Cryopreservation of organs, tissues, etc.
Journal or Publication Title: ACS Macro Letters
Publisher: American Chemical Society
ISSN: 2161-1653
Official Date: 19 September 2017
Dates:
DateEvent
19 September 2017Published
30 August 2017Available
28 August 2017Accepted
Volume: 6
Number: 9
Page Range: pp. 1001-1004
DOI: 10.1021/acsmacrolett.7b00595
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: European Research Council (ERC)
Grant number: Grant CRYOMAT 638661 (ERC)

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us