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Hormonal factors in the control of the browning of white adipose tissue
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Hu, Jiamiao and Christian, Mark (2017) Hormonal factors in the control of the browning of white adipose tissue. Hormone Molecular Biology and Clinical Investigation, 31 (1). 20170017. doi:10.1515/hmbci-2017-0017
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Official URL: http://doi.org/10.1515/hmbci-2017-0017
Abstract
Adipose tissue has been historically classified into anabolic white adipose tissue (WAT) and catabolic brown adipose tissue (BAT). Recent studies have revealed the plasticity of WAT, where white adipocytes can be induced into ‘brown-like’ heat-producing adipocytes (BRITE or beige adipocytes). Recruiting and activating BRITE adipocytes in WAT (so-called ‘browning’) is believed to provide new avenues for the treatment of obesity-related diseases. A number of hormonal factors have been found to regulate BRITE adipose development and activity through autocrine, paracrine and systemic mechanisms. In this mini-review we will discuss the impact of these factors on the browning process, especially those hormonal factors identified with direct effects on white adipocytes.
| Item Type: | Journal Article | ||||||
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| Subjects: | Q Science > QP Physiology | ||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Adipose tissues, Fat cells, Obesity -- Treatment, Metabolism -- Regulation | ||||||
| Journal or Publication Title: | Hormone Molecular Biology and Clinical Investigation | ||||||
| Publisher: | Walter de Gruyter | ||||||
| ISSN: | 1868-1883 | ||||||
| Official Date: | 21 July 2017 | ||||||
| Dates: |
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| Volume: | 31 | ||||||
| Number: | 1 | ||||||
| Article Number: | 20170017 | ||||||
| DOI: | 10.1515/hmbci-2017-0017 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access |
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