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The mechanistic link between Arc/Arg3.1 expression and AMPA receptor endocytosis

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Wall, Mark J. and Corrêa, Sônia A. L. (2018) The mechanistic link between Arc/Arg3.1 expression and AMPA receptor endocytosis. Seminars in Cell and Developmental Biology, 77 . pp. 17-24. doi:10.1016/j.semcdb.2017.09.005

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Official URL: https://doi.org/10.1016/j.semcdb.2017.09.005

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Abstract

The activity-regulated cytoskeleton associated protein (Arc/Arg3.1) plays a key role in determining synaptic strength through facilitation of AMPA receptor (AMPAR) endocytosis. Although there is considerable data on the mechanism by which Arc induction controls synaptic plasticity and learning behaviours, several key mechanistic questions remain. Here we review data on the link between Arc expression and the clathrin-mediated endocytic pathway which internalises AMPARs and discuss the significance of Arc binding to the clathrin adaptor protein 2 (AP-2) and to endophilin/dynamin. We consider which AMPAR subunits are selected for Arc-mediated internalisation, implications for synaptic function and consider Arc as a therapeutic target.

Item Type: Journal Article
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Endocytosis, Central nervous system -- Physiological aspects
Journal or Publication Title: Seminars in Cell and Developmental Biology
Publisher: Elsevier Science Ltd. / Academic Press Ltd.
ISSN: 1084-9521
Official Date: May 2018
Dates:
DateEvent
May 2018Published
7 September 2017Available
6 September 2017Accepted
Volume: 77
Page Range: pp. 17-24
DOI: 10.1016/j.semcdb.2017.09.005
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
BB/H018344/1 [BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/J02127X/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
200646/Z/16/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
UNSPECIFIEDEpilepsy Research UKhttp://dx.doi.org/10.13039/501100000295

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