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The mechanistic link between Arc/Arg3.1 expression and AMPA receptor endocytosis
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Wall, Mark J. and Corrêa, Sônia A. L. (2018) The mechanistic link between Arc/Arg3.1 expression and AMPA receptor endocytosis. Seminars in Cell and Developmental Biology, 77 . pp. 17-24. doi:10.1016/j.semcdb.2017.09.005
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Official URL: https://doi.org/10.1016/j.semcdb.2017.09.005
Abstract
The activity-regulated cytoskeleton associated protein (Arc/Arg3.1) plays a key role in determining synaptic strength through facilitation of AMPA receptor (AMPAR) endocytosis. Although there is considerable data on the mechanism by which Arc induction controls synaptic plasticity and learning behaviours, several key mechanistic questions remain. Here we review data on the link between Arc expression and the clathrin-mediated endocytic pathway which internalises AMPARs and discuss the significance of Arc binding to the clathrin adaptor protein 2 (AP-2) and to endophilin/dynamin. We consider which AMPAR subunits are selected for Arc-mediated internalisation, implications for synaptic function and consider Arc as a therapeutic target.
| Item Type: | Journal Article | |||||||||||||||
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| Subjects: | Q Science > QH Natural history > QH301 Biology | |||||||||||||||
| Divisions: | Faculty of Science > Life Sciences (2010- ) | |||||||||||||||
| Library of Congress Subject Headings (LCSH): | Endocytosis, Central nervous system -- Physiological aspects | |||||||||||||||
| Journal or Publication Title: | Seminars in Cell and Developmental Biology | |||||||||||||||
| Publisher: | Elsevier Science Ltd. / Academic Press Ltd. | |||||||||||||||
| ISSN: | 1084-9521 | |||||||||||||||
| Official Date: | May 2018 | |||||||||||||||
| Dates: |
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| Volume: | 77 | |||||||||||||||
| Page Range: | pp. 17-24 | |||||||||||||||
| DOI: | 10.1016/j.semcdb.2017.09.005 | |||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||
| Publication Status: | Published | |||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||
| RIOXX Funder/Project Grant: |
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