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The artificial pancreas : reducing safety risk via intra-peritoneal insulin delivery
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Jones, Richard W., Gianni, Francesco, Despotou, George and Katzis, Konstantinos (2017) The artificial pancreas : reducing safety risk via intra-peritoneal insulin delivery. In: Mantas, John and Hasman, Arie and Gallos, Parisis and Househ, Mowafa S. , (eds.) Informatics Empowers Healthcare Transformation. Studies in Health Technology and Informatics, 238 . IOS Press, pp. 56-59. ISBN 9781614997801
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Official URL: http://doi.org/10.3233/978-1-61499-781-8-56
Abstract
The Artificial Pancreas is a medical device, currently in development, that aims to provide automatic regulation of blood glucose (BG) levels in ambulatory type 1 diabetes mellitus sufferers. The most popular approach utilises subcutaneous (SC) continuous glucose monitoring (CGM) combined with SC insulin injection controlled by a Model Predictive Control (MPC) algorithm. From a safety risk perspective problematic elements include the performance robustness of the CGM and the need for a pre-meal insulin bolus to provide satisfactory post prandial BG regulation. This contribution presents preliminary in silico studies which indicate that the use of an alternative approach to insulin delivery - intra-peritoneal (IP) infusion - could provide a similar level of BG regulation (as obtained with SC delivery), without the need for the pre-meal bolus. This simplified control architecture would remove the patient safety risk related to the administration (or not) of pre-meal bolus.
| Item Type: | Book Item | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) |
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| Series Name: | Studies in Health Technology and Informatics | ||||
| Publisher: | IOS Press | ||||
| ISBN: | 9781614997801 | ||||
| Book Title: | Informatics Empowers Healthcare Transformation | ||||
| Editor: | Mantas, John and Hasman, Arie and Gallos, Parisis and Househ, Mowafa S. | ||||
| Official Date: | 2017 | ||||
| Dates: |
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| Volume: | 238 | ||||
| Page Range: | pp. 56-59 | ||||
| DOI: | 10.3233/978-1-61499-781-8-56 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Date of first compliant deposit: | 7 September 2017 |
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