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T-shaped peptide amphiphiles self assemble into manofiber networks
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Fisusi, Funmilola A., Notman, Rebecca, Granger, Louis A., Malkinson, John P., Schätzlein, Andreas G. and Uchegbu, Ijeoma F. (2017) T-shaped peptide amphiphiles self assemble into manofiber networks. Pharmaceutical Nanotechnology, 5 . doi:10.2174/2211738505666170828095937 ISSN 2211-7393.
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Official URL: https://doi.org/10.2174/2211738505666170828095937
Abstract
Background Conventional nanofiber forming peptide amphiphiles comprise a beta sheet forming, short peptide sequence with an alkyl chain attached at one terminus. We report the self-assembly of a peptide amphiphile possessing a mid-chain located alkyl substituent (a T-shaped peptide amphiphile) into nanofiber networks. Method Peptide synthesis was carried out using standard 9-fluorenylmethoxycarbonyl solid phase peptide synthesis protocols, followed by covalent attachment of the alkyl chains to yield target peptide amphiphiles. Self-assembly was then studied using electron microscopy and coarse grained molecular dynamics simulations. Results T-shaped peptide amphiphiles self-assembled into nanofibers just like linear peptide amphiphiles, but then unlike linear peptide amphiphiles, T-shaped peptide amphiphiles formed inter-fiber associations and ultimately nanofiber networks. Conclusion Changing the position of the alkyl chain in a peptide amphiphile from the terminal end of the peptide to the middle part of the peptide, to form a T-shaped peptide amphiphile, does not disrupt the molecular interactions required for the self-assembly of the peptide amphiphiles into nanofibers. [Abstract copyright: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.]
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
SWORD Depositor: | Library Publications Router | ||||
Journal or Publication Title: | Pharmaceutical Nanotechnology | ||||
Publisher: | Bentham Science | ||||
ISSN: | 2211-7393 | ||||
Official Date: | 27 August 2017 | ||||
Dates: |
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Volume: | 5 | ||||
DOI: | 10.2174/2211738505666170828095937 | ||||
Publication Status: | Published | ||||
Reuse Statement (publisher, data, author rights): | ** From PubMed via Jisc Publications Router. ** History: ** received: 20-03-2014 ** revised: 16-04-2014 ** accepted: 20-04-2014 | ||||
Access rights to Published version: | Restricted or Subscription Access |
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