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Recurrent seasonal outbreak of an emerging serotype of Shiga toxin-producing Escherichia coli (STEC O55:H7 stx 2a) in the south west of England, July 2014 to September 2015

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McFarland, Noëleen, Bundle, Nick, Jenkins, Claire, Godbole, Gauri, Mikhail, Amy, Dallman, Tim, O'Connor, Catherine, McCarthy, Noel D., O'Connell, Emer, Treacy, Juli et al.
(2017) Recurrent seasonal outbreak of an emerging serotype of Shiga toxin-producing Escherichia coli (STEC O55:H7 stx 2a) in the south west of England, July 2014 to September 2015. Eurosurveillance, 22 (36). 2. doi:DOI: 10.2807/1560-7917.ES.2017.22.36.30610

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Official URL: http://dx.doi.org/10.2807/1560-7917.ES.2017.22.36....

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Abstract

The first documented British outbreak of Shiga toxin-producing Escherichia coli (STEC) O55:H7 began in the county of Dorset, England, in July 2014. Since then, there have been a total of 31 cases of which 13 presented with haemolytic uraemic syndrome (HUS). The outbreak strain had Shiga toxin (stx) subtype 2a associated with an elevated risk of HUS. This strain had not previously been isolated from humans or animals in England. The only epidemiological link was living in or having close links to two areas in Dorset. Extensive investigations included testing of animals and household pets. Control measures included extended screening, iterative interviewing and exclusion of cases and high risk contacts. Whole genome sequencing (WGS) confirmed that all the cases were infected with similar strains. A specific source could not be identified. The combination of epidemiological investigation and WGS indicated, however, that this outbreak was possibly caused by recurrent introductions from a local endemic zoonotic source, that a highly similar endemic reservoir appears to exist in the Republic of Ireland but has not been identified elsewhere, and that a subset of cases was associated with human-to-human transmission in a nursery.

Item Type: Journal Article
Subjects: R Medicine > RA Public aspects of medicine
Divisions: Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET)
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Escherichia coli infections -- England -- Dorset, Verocytotoxins, Epidemiology, Medical mapping
Journal or Publication Title: Eurosurveillance
Publisher: Centre European pour la Surveillance Epidemiologique du SIDA
ISSN: 1560-7917
Official Date: September 2017
Dates:
DateEvent
September 2017Published
14 May 2017Accepted
4 November 2016Submitted
Volume: 22
Number: 36
Number of Pages: 15
Article Number: 2
DOI: DOI: 10.2807/1560-7917.ES.2017.22.36.30610
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: National Institute for Health Research (Great Britain). Health Protection Research Unit

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