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Entropy-driven genome organization

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Marenduzzo, Davide, Micheletti, C. (Cristian) and Cook, P. R.. (2006) Entropy-driven genome organization. Biophysical Journal, Vol.90 (No.10). pp. 3712-3721. ISSN 0006-3495

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Official URL: http://dx.doi.org/10.1529/biophysj.105.077685

Abstract

DNA and RNA polymerases active on bacterial and human genomes in the crowded environment of a cell are modeled as beads spaced along a string. Aggregation of the large polymerizing complexes increases the entropy of the system through an increase in entropy of the many small crowding molecules; this occurs despite the entropic costs of looping the intervening DNA. Results of a quantitative cost/benefit analysis are consistent with observations that active polymerases cluster into replication and transcription “factories” in both pro- and eukaryotes. We conclude that the second law of thermodynamics acts through nonspecific entropic forces between engaged polymerases to drive the self-organization of genomes into loops containing several thousands (and sometimes millions) of basepairs.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH426 Genetics
Divisions:	Faculty of Science > Mathematics
Library of Congress Subject Headings (LCSH):	DNA polymerases, RNA polymerases, Second law of thermodynamics, Genomics -- Mathematical models, Entropy
Journal or Publication Title:	Biophysical Journal
Publisher:	Biophysical Society
ISSN:	0006-3495
Date:	15 May 2006
Volume:	Vol.90
Number:	No.10
Page Range:	pp. 3712-3721
Identification Number:	10.1529/biophysj.105.077685
Status:	Peer Reviewed
Access rights to Published version:	Open Access
Funder:	Engineering and Physical Sciences Research Council (EPSRC)
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URI:	http://wrap.warwick.ac.uk/id/eprint/923