Entropy-driven genome organization
Marenduzzo, Davide, Micheletti, C. (Cristian) and Cook, P. R.. (2006) Entropy-driven genome organization. Biophysical Journal, Vol.90 (No.10). pp. 3712-3721. ISSN 0006-3495
WRAP_Marenduzzo_entropy-driven.pdf - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Official URL: http://dx.doi.org/10.1529/biophysj.105.077685
DNA and RNA polymerases active on bacterial and human genomes in the crowded environment of a cell are modeled as beads spaced along a string. Aggregation of the large polymerizing complexes increases the entropy of the system through an increase in entropy of the many small crowding molecules; this occurs despite the entropic costs of looping the intervening DNA. Results of a quantitative cost/benefit analysis are consistent with observations that active polymerases cluster into replication and transcription “factories” in both pro- and eukaryotes. We conclude that the second law of thermodynamics acts through nonspecific entropic forces between engaged polymerases to drive the self-organization of genomes into loops containing several thousands (and sometimes millions) of basepairs.
|Item Type:||Journal Article|
|Subjects:||Q Science > QH Natural history > QH426 Genetics|
|Divisions:||Faculty of Science > Mathematics|
|Library of Congress Subject Headings (LCSH):||DNA polymerases, RNA polymerases, Second law of thermodynamics, Genomics -- Mathematical models, Entropy|
|Journal or Publication Title:||Biophysical Journal|
|Official Date:||15 May 2006|
|Page Range:||pp. 3712-3721|
|Access rights to Published version:||Open Access|
|Funder:||Engineering and Physical Sciences Research Council (EPSRC)|
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