The Library
Entropy-driven genome organization
Tools
Marenduzzo, Davide, Micheletti, C. (Cristian) and Cook, P. R. (2006) Entropy-driven genome organization. Biophysical Journal, Vol.90 (No.10). pp. 3712-3721. doi:10.1529/biophysj.105.077685 ISSN 0006-3495.
|
PDF
WRAP_Marenduzzo_entropy-driven.pdf - Requires a PDF viewer. Download (440Kb) |
Official URL: http://dx.doi.org/10.1529/biophysj.105.077685
Abstract
DNA and RNA polymerases active on bacterial and human genomes in the crowded environment of a cell are modeled as beads spaced along a string. Aggregation of the large polymerizing complexes increases the entropy of the system through an increase in entropy of the many small crowding molecules; this occurs despite the entropic costs of looping the intervening DNA. Results of a quantitative cost/benefit analysis are consistent with observations that active polymerases cluster into replication and transcription “factories” in both pro- and eukaryotes. We conclude that the second law of thermodynamics acts through nonspecific entropic forces between engaged polymerases to drive the self-organization of genomes into loops containing several thousands (and sometimes millions) of basepairs.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | Q Science > QH Natural history > QH426 Genetics | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Mathematics | ||||
Library of Congress Subject Headings (LCSH): | DNA polymerases, RNA polymerases, Second law of thermodynamics, Genomics -- Mathematical models, Entropy | ||||
Journal or Publication Title: | Biophysical Journal | ||||
Publisher: | Biophysical Society | ||||
ISSN: | 0006-3495 | ||||
Official Date: | 15 May 2006 | ||||
Dates: |
|
||||
Volume: | Vol.90 | ||||
Number: | No.10 | ||||
Page Range: | pp. 3712-3721 | ||||
DOI: | 10.1529/biophysj.105.077685 | ||||
Status: | Peer Reviewed | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC) |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year