UNSPECIFIED (2003) The c-MYC oncoprotein as a treatment target in cancer and other disorders of cell growth. [Journal Item]

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Abstract

The c-MYC proto-oncogene is essential for cellular proliferation but, paradoxically, may also promote cell death. Deregulated expression of c-MYC is present in most, if not all, human cancers, and is associated with a poor prognosis. However, given that human tumours at diagnosis generally carry multiple genetic lesions that have accumulated during (although they are not necessarily essential for) tumour progression, it has proved difficult to attribute a specific role to any given single factor or indeed to explore the therapeutic potential of selectively mitigating their biological functions. Regulatable transgenic mouse models of oncogenesis have shed light on these issues, influenced our thinking about cancer and provided encouragement for the future development of cancer therapies based on targeting individual oncogenes such as c-MYC. Although still in its infancy, encouraging results have been reported using antisense oligodeoxynucleotide-based methods, as well as other approaches to interfere with MYC expression both in vitro and in vivo.

Item Type:	Journal Item
Subjects:	R Medicine > RS Pharmacy and materia medica
Journal or Publication Title:	EXPERT OPINION ON THERAPEUTIC TARGETS
Publisher:	ASHLEY PUBLICATIONS LTD
ISSN:	1472-8222
Date:	October 2003
Volume:	7
Number:	5
Number of Pages:	20
Page Range:	pp. 623-642
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/9230

Data sourced from Thomson Reuters' Web of Knowledge

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