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Modeling the architecture of the regulatory system controlling methylenomycin production in Streptomyces coelicolor

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Bowyer, Jack E., LC. de los Santos, Emmanuel, Styles, Kathryn, Fullwood, Alex, Corre, Christophe and Bates, Declan (2017) Modeling the architecture of the regulatory system controlling methylenomycin production in Streptomyces coelicolor. Journal of Biological Engineering, 11 (1). 30. doi:10.1186/s13036-017-0071-6

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Official URL: https://doi.org/10.1186/s13036-017-0071-6

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Abstract

The antibiotic methylenomycin A is produced naturally by Streptomyces coelicolor A3(2), a model organism for streptomycetes. This compound is of particular interest to synthetic biologists because all of the associated biosynthetic, regulatory and resistance genes are located on a single cluster on the SCP1 plasmid, making the entire module easily transferable between different bacterial strains. Understanding further the regulation and biosynthesis of the methylenomycin producing gene cluster could assist in the identification of motifs that can be exploited in synthetic regulatory systems for the rational engineering of novel natural products and antibiotics.

Item Type: Journal Article
Subjects: T Technology > TA Engineering (General). Civil engineering (General)
T Technology > TP Chemical technology
Divisions: Faculty of Science > Chemistry
Faculty of Science > Engineering
Faculty of Science > Life Sciences (2010- )
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Synthetic biology, Biotechnology, Antibiotics -- Synthesis, Methylenomycin A -- Synthesis, Genetic regulation, Mathematical models, Bayesian statistical decision theory
Journal or Publication Title: Journal of Biological Engineering
Publisher: Springer Nature
ISSN: 1754-1611
Official Date: 3 October 2017
Dates:
DateEvent
3 October 2017Published
18 July 2017Accepted
Volume: 11
Number: 1
Article Number: 30
DOI: 10.1186/s13036-017-0071-6
Status: Peer Reviewed
Publication Status: Published
Publisher Statement: ** From Crossref via Jisc Publications Router.
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIEDEngineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
BB/M017982/1Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/M022765/1Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
UF090255Royal Societyhttp://dx.doi.org/10.13039/501100000288

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