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Modeling the architecture of the regulatory system controlling methylenomycin production in Streptomyces coelicolor
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Bowyer, Jack E., LC. de los Santos, Emmanuel, Styles, Kathryn, Fullwood, Alex, Corre, Christophe and Bates, Declan (2017) Modeling the architecture of the regulatory system controlling methylenomycin production in Streptomyces coelicolor. Journal of Biological Engineering, 11 (1). 30. doi:10.1186/s13036-017-0071-6
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Official URL: https://doi.org/10.1186/s13036-017-0071-6
Abstract
The antibiotic methylenomycin A is produced naturally by Streptomyces coelicolor A3(2), a model organism for streptomycetes. This compound is of particular interest to synthetic biologists because all of the associated biosynthetic, regulatory and resistance genes are located on a single cluster on the SCP1 plasmid, making the entire module easily transferable between different bacterial strains. Understanding further the regulation and biosynthesis of the methylenomycin producing gene cluster could assist in the identification of motifs that can be exploited in synthetic regulatory systems for the rational engineering of novel natural products and antibiotics.
| Item Type: | Journal Article | |||||||||||||||
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| Subjects: | T Technology > TA Engineering (General). Civil engineering (General) T Technology > TP Chemical technology |
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| Divisions: | Faculty of Science > Chemistry Faculty of Science > Engineering Faculty of Science > Life Sciences (2010- ) |
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| SWORD Depositor: | Library Publications Router | |||||||||||||||
| Library of Congress Subject Headings (LCSH): | Synthetic biology., Biotechnology., Antibiotics—Synthesis, Methylenomycin A -- Synthesis., Genetic regulation., Mathematical models., Bayesian statistical decision theory. | |||||||||||||||
| Journal or Publication Title: | Journal of Biological Engineering | |||||||||||||||
| Publisher: | Springer Nature | |||||||||||||||
| ISSN: | 1754-1611 | |||||||||||||||
| Official Date: | 3 October 2017 | |||||||||||||||
| Dates: |
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| Date of first compliant deposit: | 10 October 2017 | |||||||||||||||
| Volume: | 11 | |||||||||||||||
| Number: | 1 | |||||||||||||||
| Article Number: | 30 | |||||||||||||||
| DOI: | 10.1186/s13036-017-0071-6 | |||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||
| Publication Status: | Published | |||||||||||||||
| Publisher Statement: | ** From Crossref via Jisc Publications Router. | |||||||||||||||
| Access rights to Published version: | Open Access | |||||||||||||||
| RIOXX Funder/Project Grant: |
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