UNSPECIFIED (2003) Regulation of [Ca2+](c) oscillations by plasma membrane Ca2+ fluxes: a role for natriuretic peptides. In: 5th UK Calcium Signalling Conference, MAY 01-02, 2003, UNIV LIVERPOOL, LIVERPOOL, ENGLAND.

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Abstract

We have investigated the effects of natriuretic peptides on oscillations in [Ca2+](c) (cytosolic free Ca2+ concentration) in two different cell types: freshly isolated rat hepatocytes and the ECV304 cell line. Our data, from both cell types, suggest that natriuretic peptides modulate the frequency of [Ca2+](c) oscillations through alterations in plasma membrane Ca2+ fluxes. Here, we review evidence for a role for plasma membrane Ca2+ fluxes in the control of the frequency of [Ca2+](c) oscillations. We describe a hypothetical mechanism through which this might be achieved. We propose a physiological role for regulated control of Ca2+ efflux in modulating [Ca2+](c) oscillations.

Item Type:	Conference Item (UNSPECIFIED)
Subjects:	Q Science > QD Chemistry
Journal or Publication Title:	BIOCHEMICAL SOCIETY TRANSACTIONS
Publisher:	PORTLAND PRESS
ISSN:	0300-5127
Date:	October 2003
Volume:	31
Number:	Part 5
Number of Pages:	5
Page Range:	pp. 934-938
Publication Status:	Published
Title of Event:	5th UK Calcium Signalling Conference
Location of Event:	UNIV LIVERPOOL, LIVERPOOL, ENGLAND
Date(s) of Event:	MAY 01-02, 2003
URI:	http://wrap.warwick.ac.uk/id/eprint/9235

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