Synthesis of novel nucleo-beta-amino acids and nucleobase-functionalized beta-peptides
UNSPECIFIED. (2003) Synthesis of novel nucleo-beta-amino acids and nucleobase-functionalized beta-peptides. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (18). pp. 3555-3561. ISSN 1434-193XFull text not available from this repository.
Official URL: http://dx.doi.org/10.1002/ejoc.200300269
Four novel beta-amino acids bearing the canonical nucleobases guanine, cytosine, adenine, and thymine in the side chain, are synthesized starting from BOC-L-aspartic acid 4-benzyl ester. The syntheses are accomplished in six steps by the nucleophilic substitution of (S)-beta-(tert-butoxycarbonylamino)-delta-bromopentanoic acid benzyl ester with the corresponding nucleobase derivative as the key step. The guaninyl and cytosinyl beta-amino acids were built into beta-peptides that were studied by temperature-dependent CD and UV spectroscopy. (C) Wiley-VCH Verlag GmbH Co.
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry|
|Journal or Publication Title:||EUROPEAN JOURNAL OF ORGANIC CHEMISTRY|
|Publisher:||WILEY-V C H VERLAG GMBH|
|Date:||15 September 2003|
|Number of Pages:||7|
|Page Range:||pp. 3555-3561|
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