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Synthesis of novel nucleo-beta-amino acids and nucleobase-functionalized beta-peptides
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UNSPECIFIED. (2003) Synthesis of novel nucleo-beta-amino acids and nucleobase-functionalized beta-peptides. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (18). pp. 3555-3561. ISSN 1434-193X
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Official URL: http://dx.doi.org/10.1002/ejoc.200300269
Abstract
Four novel beta-amino acids bearing the canonical nucleobases guanine, cytosine, adenine, and thymine in the side chain, are synthesized starting from BOC-L-aspartic acid 4-benzyl ester. The syntheses are accomplished in six steps by the nucleophilic substitution of (S)-beta-(tert-butoxycarbonylamino)-delta-bromopentanoic acid benzyl ester with the corresponding nucleobase derivative as the key step. The guaninyl and cytosinyl beta-amino acids were built into beta-peptides that were studied by temperature-dependent CD and UV spectroscopy. (C) Wiley-VCH Verlag GmbH Co.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry |
| Journal or Publication Title: | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY |
| Publisher: | WILEY-V C H VERLAG GMBH |
| ISSN: | 1434-193X |
| Date: | 15 September 2003 |
| Number: | 18 |
| Number of Pages: | 7 |
| Page Range: | pp. 3555-3561 |
| Identification Number: | 10.1002/ejoc.200300269 |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/9279 |
Data sourced from Thomson Reuters' Web of Knowledge
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