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Heart rate variability and salivary cortisol in very preterm children during school age
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Urfer-Maurer, Natalie, Ludyga, Sebastian, Stalder, Tobias, Brand, Serge, Holsboer-Trachsler, Edith, Gerber, Markus, Grob, Alexander, Weber, Peter and Lemola, Sakari (2018) Heart rate variability and salivary cortisol in very preterm children during school age. Psychoneuroendocrinology, 87 . pp. 27-34. doi:10.1016/j.psyneuen.2017.10.004
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Official URL: http://dx.doi.org/10.1016/j.psyneuen.2017.10.004
Abstract
The autonomic nervous system (ANS) plays a major role in the human stress response and reflects physical and psychological adaptability to a changing environment. Long-term exposure to early life stressors may alter the function of the ANS. The present study examines differences in the ANS between children born very preterm and full-term as well as the association between the ANS and the hypothalamic-pituitary-adrenal (HPA) axis, the other main branch of the human stress system.
Fifty-four healthy children born very preterm (<32nd gestational week) and 67 full-term children aged 7–12 years provided data for the present study. Polysomnography (PSG) assessments were obtained during a night at the children’s home in lying position at rest (wake) and during different sleep stages (stage 2 sleep, slow wave sleep, rapid-eye-movement sleep). Autonomic function was assessed by use of heart rate variability, specifically low frequency power (LF), high frequency power (HF), total spectral power (Tot Pow), and the LF/HF ratio. HPA axis activity was measured using salivary cortisol the next morning at awakening, 10, 20, and 30 min later.
Children born very preterm had lower LF/HF ratio during wake and stage 2 sleep compared to full-term children. Moreover, higher LF, Tot Pow, and LF/HF ratio during wake, stage 2 sleep, and REM sleep were related to more post-awakening cortisol secretion.
The present study provides evidence on long-term ANS alterations after very preterm birth. Moreover, findings suggest a relation between the ANS and the HPA axis and therefore support the notion of mutual feedback between the two human stress systems.
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QP Physiology | ||||||||
| Divisions: | Faculty of Science > Psychology | ||||||||
| Library of Congress Subject Headings (LCSH): | Autonomic nervous system, Hypothalamic-pituitary-adrenal axis, Stress (Physiology), Premature infants, Polysomnography, Heart beat -- Measurement | ||||||||
| Journal or Publication Title: | Psychoneuroendocrinology | ||||||||
| Publisher: | Pergamon | ||||||||
| ISSN: | 0306-4530 | ||||||||
| Official Date: | January 2018 | ||||||||
| Dates: |
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| Volume: | 87 | ||||||||
| Page Range: | pp. 27-34 | ||||||||
| DOI: | 10.1016/j.psyneuen.2017.10.004 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Funder: | Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung [Swiss National Science Foundation] (SNSF), Universität Basel | ||||||||
| Grant number: | 143962 (SNSF), 159362 (SNSF), DPE2083 (UB) |
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