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Combining epidemiology with basic biology of sand flies, parasites, and hosts to inform leishmaniasis transmission dynamics and control
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Courtenay, Orin, Peters, Nathan C., Rogers, Matthew E. and Bern, Caryn (2017) Combining epidemiology with basic biology of sand flies, parasites, and hosts to inform leishmaniasis transmission dynamics and control. PLOS Pathogens, 13 (10). e1006571. doi:10.1371/journal.ppat.1006571 ISSN 1553-7374.
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Official URL: http://doi.org/10.1371/journal.ppat.1006571
Abstract
Quantitation of the nonlinear heterogeneities in Leishmania parasites, sand fly vectors, and mammalian host relationships provides insights to better understand leishmanial transmission epidemiology towards improving its control. The parasite manipulates the sand fly via production of promastigote secretory gel (PSG), leading to the “blocked sand fly” phenotype, persistent feeding attempts, and feeding on multiple hosts. PSG is injected into the mammalian host with the parasite and promotes the establishment of infection. Animal models demonstrate that sand flies with the highest parasite loads and percent metacyclic promastigotes transmit more parasites with greater frequency, resulting in higher load infections that are more likely to be both symptomatic and efficient reservoirs. The existence of mammalian and sand fly “super-spreaders” provides a biological basis for the spatial and temporal clustering of clinical leishmanial disease. Sand fly blood-feeding behavior will determine the efficacies of indoor residual spraying, topical insecticides, and bed nets. Interventions need to have sufficient coverage to include transmission hot spots, especially in the absence of field tools to assess infectiousness. Interventions that reduce sand fly densities in the absence of elimination could have negative consequences, for example, by interfering with partial immunity conferred by exposure to sand fly saliva. A deeper understanding of both sand fly and host biology and behavior is essential to ensuring effectiveness of vector interventions.
| Item Type: | Journal Article | ||||||||||||
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| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine | ||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||||
| SWORD Depositor: | Library Publications Router | ||||||||||||
| Library of Congress Subject Headings (LCSH): | Leishmaniasis -- Infection -- Prevention, Leishmaniasis -- Epidemiology | ||||||||||||
| Journal or Publication Title: | PLOS Pathogens | ||||||||||||
| Publisher: | Public Library of Science | ||||||||||||
| ISSN: | 1553-7374 | ||||||||||||
| Official Date: | 19 October 2017 | ||||||||||||
| Dates: |
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| Volume: | 13 | ||||||||||||
| Number: | 10 | ||||||||||||
| Article Number: | e1006571 | ||||||||||||
| DOI: | 10.1371/journal.ppat.1006571 | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | Published | ||||||||||||
| Reuse Statement (publisher, data, author rights): | ** From PLOS via Jisc Publications Router. ** History: ** collection: 10-2017 ** epub: 19-10-2017 ** Licence for this article: http://creativecommons.org/licenses/by/4.0/ | ||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||
| Date of first compliant deposit: | 9 November 2017 | ||||||||||||
| Date of first compliant Open Access: | 9 November 2017 | ||||||||||||
| RIOXX Funder/Project Grant: |
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