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Combining epidemiology with basic biology of sand flies, parasites, and hosts to inform leishmaniasis transmission dynamics and control

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Courtenay, Orin, Peters, Nathan C., Rogers, Matthew E. and Bern, Caryn (2017) Combining epidemiology with basic biology of sand flies, parasites, and hosts to inform leishmaniasis transmission dynamics and control. PLOS Pathogens, 13 (10). e1006571. doi:10.1371/journal.ppat.1006571

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Official URL: http://doi.org/10.1371/journal.ppat.1006571

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Abstract

Quantitation of the nonlinear heterogeneities in Leishmania parasites, sand fly vectors, and mammalian host relationships provides insights to better understand leishmanial transmission epidemiology towards improving its control. The parasite manipulates the sand fly via production of promastigote secretory gel (PSG), leading to the “blocked sand fly” phenotype, persistent feeding attempts, and feeding on multiple hosts. PSG is injected into the mammalian host with the parasite and promotes the establishment of infection. Animal models demonstrate that sand flies with the highest parasite loads and percent metacyclic promastigotes transmit more parasites with greater frequency, resulting in higher load infections that are more likely to be both symptomatic and efficient reservoirs. The existence of mammalian and sand fly “super-spreaders” provides a biological basis for the spatial and temporal clustering of clinical leishmanial disease. Sand fly blood-feeding behavior will determine the efficacies of indoor residual spraying, topical insecticides, and bed nets. Interventions need to have sufficient coverage to include transmission hot spots, especially in the absence of field tools to assess infectiousness. Interventions that reduce sand fly densities in the absence of elimination could have negative consequences, for example, by interfering with partial immunity conferred by exposure to sand fly saliva. A deeper understanding of both sand fly and host biology and behavior is essential to ensuring effectiveness of vector interventions.

Item Type: Journal Article
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions: Faculty of Science > Life Sciences (2010- )
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Leishmaniasis -- Infection -- Prevention, Leishmaniasis -- Epidemiology
Journal or Publication Title: PLOS Pathogens
Publisher: Public Library of Science
ISSN: 1553-7374
Official Date: 19 October 2017
Dates:
DateEvent
19 October 2017Published
15 August 2017Accepted
Volume: 13
Number: 10
Article Number: e1006571
DOI: 10.1371/journal.ppat.1006571
Status: Peer Reviewed
Publication Status: Published
Publisher Statement: ** From PLOS via Jisc Publications Router. ** History: ** collection: 10-2017 ** epub: 19-10-2017 ** Licence for this article: http://creativecommons.org/licenses/by/4.0/
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIEDWellcome Trusthttp://dx.doi.org/10.13039/100004440
MOP-142302Canadian Institutes of Health Researchhttp://dx.doi.org/10.13039/501100000024
BB/H022406 /1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
Contributors:
ContributionNameContributor ID
UNSPECIFIEDGubbels, Marc-JanUNSPECIFIED

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