Antigen presentation on MHC molecules as a diversity filter that enhances immune efficacy
UNSPECIFIED. (2003) Antigen presentation on MHC molecules as a diversity filter that enhances immune efficacy. JOURNAL OF THEORETICAL BIOLOGY, 224 (2). pp. 249-267. ISSN 0022-5193Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/S0022-5193(03)00162-0
We consider the way in which antigen is presented to T cells on MHC molecules and ask how MHC peptide presentation could be optimized so as to obtain an effective and safe immune response. By analysing this problem with a mathematical model of T-cell activation, we deduce the need for both MHC restriction and high presentation selectivity. We find that the optimal selectivity is such that about one pathogen-derived peptide is presented per MHC isoform. on the average. We also indicate upper and lower bounds to the number of MHC isoforms per individual based on detectability requirements. Thus we deduce that an important role of MHC presentation is to act as a filter that limits the diversity of antigen presentation. (C) 2003 Elsevier Ltd. All rights reserved.
|Item Type:||Journal Article|
|Subjects:||Q Science > QH Natural history > QH301 Biology|
|Journal or Publication Title:||JOURNAL OF THEORETICAL BIOLOGY|
|Publisher:||ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD|
|Date:||21 September 2003|
|Number of Pages:||19|
|Page Range:||pp. 249-267|
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