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Self-assembly and dis-assembly of stimuli responsive tadpole-like single chain nanoparticles using a switchable hydrophilic/hydrophobic boronic acid cross-linker

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Zhang, Junliang, Tanaka, Joji, Gurnani, Pratik, Wilson, Paul, Hartlieb, Matthias and Perrier, Sébastien (2017) Self-assembly and dis-assembly of stimuli responsive tadpole-like single chain nanoparticles using a switchable hydrophilic/hydrophobic boronic acid cross-linker. Polymer Chemistry, 28 (8). pp. 4079-4087. doi:DOI: 10.1039/C7PY00828G

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Official URL: http://dx.doi.org/10.1039/C7PY00828G

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Abstract

Living systems are driven by molecular machines that are composed of folded polypeptide chains, which are assembled together to form multimeric complexes. Although replicating this type of system is a longstanding goal in polymer science, the complexity the structures impose is synthetically very challenging, and generating synthetic polymers to mimic the process of these assemblies appears to be a more appealing approach. To this end, we report a linear polymer programmable for stepwise folding and assembly to higher order structures. To achieve this, a diblock copolymer composed of 4-acryloylmorpholine and glycerol acrylate was synthesised with high precision via reversible addition fragmentation chain transfer polymerisation (Đ < 1.22). Both intramolecular folding and intermolecular assembly were driven by a pH responsive cross-linker, benzene-1,4-diboronic acid. The resulting intramolecular folded single chain nanoparticles were well defined (Đ < 1.16) and successfully assembled into a multimeric structure (Dh = 245 nm) at neutral pH with no chain entanglement. The assembled multimer was observed with a spherical morphology as confirmed by TEM and AFM. These structures were capable of unfolding and disassembling either at low pH or in the presence of sugar. This work offers a new perspective for the generation of adaptive smart materials.

Item Type: Journal Article
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Journal or Publication Title: Polymer Chemistry
Publisher: Royal Society of Chemistry
ISSN: 1759-9954
Official Date: 6 June 2017
Dates:
DateEvent
6 June 2017Published
5 June 2017Accepted
18 May 2017Submitted
Volume: 28
Number: 8
Page Range: pp. 4079-4087
DOI: DOI: 10.1039/C7PY00828G
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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