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Binding of hydrophobic guests in a coordination cage cavity is driven by liberation of 'high-energy' water
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Metherell, Alexander J., Cullen, William, Williams, Nicholas H. and Ward, Michael D. (2018) Binding of hydrophobic guests in a coordination cage cavity is driven by liberation of 'high-energy' water. Chemistry - A European Journal, 24 (7). pp. 1554-1560. doi:10.1002/chem.201704163 ISSN 0947-6539.
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Official URL: http://dx.doi.org/10.1002/chem.201704163
Abstract
The cavity of an M8L12 cubic coordination cage can accommodate a cluster of ten water molecules in which the average number of hydrogen bonds per water molecule is 0.5 H-bonds less than it would be in the bulk solution. The presence of these 'hydrogen-bond frustrated' or 'high-energy' water molecules in the cavity results in the hydrophobic effect associated with guest binding being predominantly enthalpy-based, as these water molecules can improve their hydrogen-bonding environment on release. This contrasts with the classical form of the hydrophobic effect in which the favourable entropy change associated with release of ordered molecules from hydrophobic surfaces dominates. For several guests Van't Hoff plots showed that the free energy of binding in water is primarily enthalpy-driven. For five homologous pairs of guests related by the presence or absence of a CH2 group, the incremental changes to ∆H and T∆S for guest binding ¬- i.e. ∆∆H and T∆∆S, the difference in contributions arising from the CH2 group - are consistently 5±1 kJ mol-1 for ∆∆H and 0±1 kJ mol-1 for T∆∆S. This systematic dominance of ∆H in the binding of hydrophobic guests is consistent with the view that guest binding is dominated by release of 'high energy' water molecules into a more favourable solvation environment, as has been demonstrated recently for some members of the cucurbituril family.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QD Chemistry | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
Library of Congress Subject Headings (LCSH): | Supramolecular chemistry., Surface chemistry., Solution (Chemistry) | ||||||||
Journal or Publication Title: | Chemistry - A European Journal | ||||||||
Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | ||||||||
ISSN: | 0947-6539 | ||||||||
Official Date: | 1 February 2018 | ||||||||
Dates: |
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Volume: | 24 | ||||||||
Number: | 7 | ||||||||
Page Range: | pp. 1554-1560 | ||||||||
DOI: | 10.1002/chem.201704163 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 7 November 2017 | ||||||||
Date of first compliant Open Access: | 28 February 2018 | ||||||||
RIOXX Funder/Project Grant: |
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