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Estimation of saliva cotinine cut-off points for active and passive smoking during pregnancy—polish mother and child cohort (REPRO_PL)
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Polanska, Kinga, Krol, Anna, Kaluzny, Pawel, Ligocka, Danuta, Mikolajewska, Karolina, Shaheen, Seif, Walton, Robert T. and Hanke, Wojciech (2016) Estimation of saliva cotinine cut-off points for active and passive smoking during pregnancy—polish mother and child cohort (REPRO_PL). International Journal of Environmental Research and Public Health, 13 (12). 1216. doi:10.3390/ijerph13121216 ISSN 1660-4601.
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Official URL: http://dx.doi.org/10.3390/ijerph13121216
Abstract
A reliable assessment of smoking status has significant public health implications and is essential for research purposes. The aim of this study was to determine optimal saliva cotinine cut-off values for smoking during pregnancy. The analyses were based on data from 1771 women from the Polish Mother and Child Cohort. Saliva cotinine concentrations were assessed by high performance liquid chromatography coupled with tandem mass spectrometry (HPLC-ESI + MS/MS). The saliva cotinine cut-off value for active smoking was established at 10 ng/mL (sensitivity 96%, specificity 95%) and for passive smoking at 1.5 ng/mL (sensitivity 63%, specificity 71%). About 5% of the self-reported non-smoking women were classified as smokers based on the cotinine cut-off value. Significantly more younger, single, and less educated self-reported non-smokers had a cotinine concentration higher than 10 ng/mL compared to those who were older, married, and who had a university degree. Close to 30% of the non-smokers who indicated that smoking was not allowed in their home could be classified as exposed to passive smoking based on the cut-off value. The study suggests that self-reported smoking status is a valid measure of active smoking, whereas in the case of passive smoking, a combination of questionnaire data and biomarker verification may be required.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | International Journal of Environmental Research and Public Health | ||||||
Publisher: | M D P I AG | ||||||
ISSN: | 1660-4601 | ||||||
Official Date: | 8 December 2016 | ||||||
Dates: |
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Volume: | 13 | ||||||
Number: | 12 | ||||||
Article Number: | 1216 | ||||||
DOI: | 10.3390/ijerph13121216 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published |
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