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Unlocking the potential of poly(ortho ester)s : a general catalytic approach to the synthesis of surface erodible materials
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Tschan, Mathieu, Ieong, Nga Sze, Todd, Richard and Dove, Andrew P. (2017) Unlocking the potential of poly(ortho ester)s : a general catalytic approach to the synthesis of surface erodible materials. Angewandte Chemie (International Edition) . doi:10.1002/anie.201709934 ISSN 1433-7851.
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Official URL: http://doi.org/10.1002/anie.201709934
Abstract
Poly(ortho ester)s, POEs, are well established as displaying surface eroding properties and hence present unique opportunities for controlled release and tissue engineering applications. Their development and wide spread investigation has however been severely limited by challenging synthetic requirements via unstable intermediates and is therefore highly irreproducible. Herein, we present the first catalytic method for the synthesis of POEs using air and moisture stable vinyl acetal precursors. The synthesis of a range of POE structures is demonstrated including those that are extremely hard to achieve by other synthetic methodologies. Furthermore, we demonstrate that the application of this chemistry to efficiently install functional groups via ortho ester linkages to an aliphatic polycarbonate.
| Item Type: | Journal Article | ||||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||
| SWORD Depositor: | Library Publications Router | ||||||
| Journal or Publication Title: | Angewandte Chemie (International Edition) | ||||||
| Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | ||||||
| ISSN: | 1433-7851 | ||||||
| Official Date: | 31 October 2017 | ||||||
| Dates: |
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| DOI: | 10.1002/anie.201709934 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Reuse Statement (publisher, data, author rights): | ** From PubMed via Jisc Publications Router. ** History: received 26-09-2017; accepted 25-10-2017; revised 25-10-2017. | ||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||
| Date of first compliant deposit: | 28 November 2017 | ||||||
| Date of first compliant Open Access: | 31 October 2018 |
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