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pH responsive glycopolymer nanoparticles for targeted delivery of anti-cancer drugs
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Yilmaz, Gokhan, Guler, Emine, Geyik, Caner, Demir, Bilal, Ozkan, Melek, Odaci Demirkol, Dilek, Ozcelik, Serdar, Timur, Suna and Becer, C. Remzi (2018) pH responsive glycopolymer nanoparticles for targeted delivery of anti-cancer drugs. Molecular Systems Design & Engineering . doi:10.1039/c7me00086c ISSN 2058-9689.
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Official URL: https://doi.org/10.1039/c7me00086c
Abstract
Over the past decade, there has been a great deal of interest in the integration of nanotechnology and carbohydrates. The advances in glyconanotechnology have allowed the creation of different bioactive glyconanostructures for different types of medical applications, especially for drug delivery and release systems. Therefore, the use of more efficient biocompatible nanocarriers with high loading capacity, low overall toxicity and receptor-mediated endocytosis specificity is still in focus for the enhancement of the therapeutic effect. Conjugation of sugar derivatives onto gold nanoparticles presents unique properties that include a wide array of assembling models and size-related electronic, magnetic and optical properties. Here, pH-responsive drug-conjugated glycopolymer-coated gold nanoparticles were prepared by functionalization of gold nanoparticles with thiol-terminated glycopolymers and then subsequent conjugation of doxorubicin (DOX). Among the four different glycopolymers, their drug release, physicochemical characterization (spectroscopy, particle size and surface charge) and in vitro bioapplications with four different cell lines were compared. As a result, pH-sensitive drug delivery via sugar-coated AuNPs was performed thanks to hydrazone linkages between glycopolymers and DOX. Comparative viability tests also demonstrated the efficiency of glycopolymer–DOX conjugates by fluorescence cell imaging. The obtained results reveal that AuNP homoglycopolymer DOX conjugates (P4D) have significant potential, especially in human neuroblastoma cells in comparison to cervical cancer cells and lung cancer cells.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
SWORD Depositor: | Library Publications Router | ||||
Journal or Publication Title: | Molecular Systems Design & Engineering | ||||
Publisher: | Royal Society of Chemistry (RSC) | ||||
ISSN: | 2058-9689 | ||||
Official Date: | 2018 | ||||
Dates: |
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DOI: | 10.1039/c7me00086c | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Reuse Statement (publisher, data, author rights): | ** From Crossref via Jisc Publications Router. | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
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