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Polymer mimics of biomacromolecular antifreezes
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Biggs, Caroline I., Bailey, Trisha L., Graham, Ben, Stubbs, Christopher D., Fayter, Alice and Gibson, Matthew I. (2017) Polymer mimics of biomacromolecular antifreezes. Nature Communications, 8 . 1546. doi:10.1038/s41467-017-01421-7 ISSN 2041-1723.
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Official URL: http://doi.org/10.1038/s41467-017-01421-7
Abstract
Antifreeze proteins from polar fish species are remarkable biomacromolecules which prevent the growth of ice crystals. Ice crystal growth is a major problem in cell/tissue cryopreservation for transplantation, transfusion and basic biomedical research, as well as technological applications such as icing of aircraft wings. This review will introduce the rapidly emerging field of synthetic macromolecular (polymer) mimics of antifreeze proteins. Particular focus is placed on designing polymers which have no structural similarities to antifreeze proteins but reproduce the same macroscopic properties, potentially by different molecular-level mechanisms. The application of these polymers to the cryopreservation of donor cells is also introduced.
Item Type: | Journal Article | ||||||||||||||||||
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Subjects: | Q Science > QD Chemistry Q Science > QH Natural history |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Cells -- Cryopreservation, Antifreeze proteins, Polymers | ||||||||||||||||||
Journal or Publication Title: | Nature Communications | ||||||||||||||||||
Publisher: | Nature Publishing Group | ||||||||||||||||||
ISSN: | 2041-1723 | ||||||||||||||||||
Official Date: | 16 November 2017 | ||||||||||||||||||
Dates: |
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Volume: | 8 | ||||||||||||||||||
Article Number: | 1546 | ||||||||||||||||||
DOI: | 10.1038/s41467-017-01421-7 | ||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||
Date of first compliant deposit: | 14 November 2017 | ||||||||||||||||||
Date of first compliant Open Access: | 21 November 2017 | ||||||||||||||||||
RIOXX Funder/Project Grant: |
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