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Weak molecular interactions in clathrin-mediated endocytosis
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Smith, Sarah Marie, Baker, Michael, Halebian, Mary and Smith, Corinne J. (2017) Weak molecular interactions in clathrin-mediated endocytosis. Frontiers in Molecular Biosciences, 4 . 72. doi:10.3389/fmolb.2017.00072 ISSN 2296-889X.
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Official URL: http://dx.doi.org/10.3389/fmolb.2017.00072
Abstract
Clathrin-mediated endocytosis is a process by which specific molecules are internalized from the cell periphery for delivery to early endosomes. The key stages in this step-wise process, from the starting point of cargo recognition, to the later stage of assembly of the clathrin coat, are dependent on weak interactions between a large network of proteins. This review discusses the structural and functional data that have improved our knowledge and understanding of the main weak molecular interactions implicated in clathrin-mediated endocytosis, with a particular focus on the two key proteins: AP2 and clathrin.
Item Type: | Journal Article | ||||||||||||||||||
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Subjects: | Q Science > QH Natural history | ||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Endocytosis, Endosomes | ||||||||||||||||||
Journal or Publication Title: | Frontiers in Molecular Biosciences | ||||||||||||||||||
Publisher: | Frontiers Media | ||||||||||||||||||
ISSN: | 2296-889X | ||||||||||||||||||
Official Date: | 14 November 2017 | ||||||||||||||||||
Dates: |
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Volume: | 4 | ||||||||||||||||||
Article Number: | 72 | ||||||||||||||||||
DOI: | 10.3389/fmolb.2017.00072 | ||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||
Date of first compliant deposit: | 14 November 2017 | ||||||||||||||||||
Date of first compliant Open Access: | 14 November 2017 | ||||||||||||||||||
RIOXX Funder/Project Grant: |
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