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Cofibrillization of pathogenic and functional amyloid proteins with gold nanoparticles against amyloidogenesis
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Javed, Ibrahim, Sun, Yunxiang, Adamcik, Jozef, Wang, Bo, Kakinen, Aleksandr, Pilkington, Emily H., Ding, Feng, Mezzenga, Raffaele, Davis, Thomas P. and Ke, Pu Chun (2017) Cofibrillization of pathogenic and functional amyloid proteins with gold nanoparticles against amyloidogenesis. Biomacromolecules, 18 (12). pp. 4316-4322. doi:10.1021/acs.biomac.7b01359
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WRAP-co-fibrillization-pathogenic-functional-amyloid-proteins-Davis-2017.pdf - Accepted Version - Requires a PDF viewer. Download (1696Kb) | Preview |
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Official URL: http://dx.doi.org/10.1021/acs.biomac.7b01359
Abstract
Biomimetic nanocomposites and scaffolds hold the key to a wide range of biomedical applications. Here we show, for the first time, a facile scheme of cofibrillizing pathogenic and functional amyloid fibrils via gold nanoparticles (AuNPs) and their applications against amyloidogenesis. This scheme was realized by β-sheet stacking between human islet amyloid polypeptide (IAPP) and the β-lactoglobulin “corona” of the AuNPs, as revealed by transmission electron microscopy, 3D atomic force microscopy, circular dichroism spectroscopy, and molecular dynamics simulations. The biomimetic AuNPs eliminated IAPP toxicity, enabled X-ray destruction of IAPP amyloids, and allowed dark-field imaging of pathogenic amyloids and their immunogenic response by human T cells. In addition to providing a viable new nanotechnology against amyloidogenesis, this study has implications for understanding the in vivo cross-talk between amyloid proteins of different pathologies.
| Item Type: | Journal Article | |||||||||||||||
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| Subjects: | Q Science > QP Physiology R Medicine > RB Pathology |
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| Divisions: | Faculty of Science > Chemistry | |||||||||||||||
| Library of Congress Subject Headings (LCSH): | Amyloid, Biomimetics, Pathology | |||||||||||||||
| Journal or Publication Title: | Biomacromolecules | |||||||||||||||
| Publisher: | American Chemical Society | |||||||||||||||
| ISSN: | 1525-7797 | |||||||||||||||
| Official Date: | 11 December 2017 | |||||||||||||||
| Dates: |
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| Date of first compliant deposit: | 16 November 2017 | |||||||||||||||
| Volume: | 18 | |||||||||||||||
| Number: | 12 | |||||||||||||||
| Page Range: | pp. 4316-4322 | |||||||||||||||
| DOI: | 10.1021/acs.biomac.7b01359 | |||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||
| Publication Status: | Published | |||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||
| Funder: | Monash University. Institute of Pharmaceutical Sciences | |||||||||||||||
| RIOXX Funder/Project Grant: |
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