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Cofibrillization of pathogenic and functional amyloid proteins with gold nanoparticles against amyloidogenesis

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Javed, Ibrahim, Sun, Yunxiang, Adamcik, Jozef, Wang, Bo, Kakinen, Aleksandr, Pilkington, Emily H., Ding, Feng, Mezzenga, Raffaele, Davis, Thomas P. and Ke, Pu Chun (2017) Cofibrillization of pathogenic and functional amyloid proteins with gold nanoparticles against amyloidogenesis. Biomacromolecules, 18 (12). pp. 4316-4322. doi:10.1021/acs.biomac.7b01359 ISSN 1525-7797.

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Official URL: http://dx.doi.org/10.1021/acs.biomac.7b01359

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Abstract

Biomimetic nanocomposites and scaffolds hold the key to a wide range of biomedical applications. Here we show, for the first time, a facile scheme of cofibrillizing pathogenic and functional amyloid fibrils via gold nanoparticles (AuNPs) and their applications against amyloidogenesis. This scheme was realized by β-sheet stacking between human islet amyloid polypeptide (IAPP) and the β-lactoglobulin “corona” of the AuNPs, as revealed by transmission electron microscopy, 3D atomic force microscopy, circular dichroism spectroscopy, and molecular dynamics simulations. The biomimetic AuNPs eliminated IAPP toxicity, enabled X-ray destruction of IAPP amyloids, and allowed dark-field imaging of pathogenic amyloids and their immunogenic response by human T cells. In addition to providing a viable new nanotechnology against amyloidogenesis, this study has implications for understanding the in vivo cross-talk between amyloid proteins of different pathologies.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
R Medicine > RB Pathology
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH): Amyloid, Biomimetics, Pathology
Journal or Publication Title: Biomacromolecules
Publisher: American Chemical Society
ISSN: 1525-7797
Official Date: 11 December 2017
Dates:
DateEvent
11 December 2017Published
2 November 2017Available
31 October 2017Accepted
Volume: 18
Number: 12
Page Range: pp. 4316-4322
DOI: 10.1021/acs.biomac.7b01359
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Date of first compliant deposit: 16 November 2017
Date of first compliant Open Access: 2 November 2018
Funder: Monash University. Institute of Pharmaceutical Sciences
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
Project No. CE140100036Australian Research Councilhttp://dx.doi.org/10.13039/501100000923
Grant CBET - 1553945National Science Foundationhttp://dx.doi.org/10.13039/100000001
R35GM119691National Institutes of Healthhttp://dx.doi.org/10.13039/100000002
UNSPECIFIEDMonash University. Institute of Pharmaceutical SciencesUNSPECIFIED

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