UNSPECIFIED (2003) Investigation of the effects of various parameters on the synthesis of oligopeptides in aqueous solution. EUROPEAN POLYMER JOURNAL, 39 (8). pp. 1559-1565. ISSN 0014-3057

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Abstract

Oligomerization efficiency of amino acids in aqueous solution has been compared under different conditions (temperature, activating agent, etc.) using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and 1,1'-carbonyldiimidazole (CDI) as coupling agents. Glycine (H2N-CH2-COOH) and alpha-alanine (H2N-CH(CH3)-COOH) were chosen as alpha-amino acids and beta-alanine (H2N-CH2-CH2-COOH) as the beta-amino acid. The coupling reaction between EDC and glycine was shown to occur but does not go to completion either at ambient temperature or at 70 degreesC. The presence of a carboxylic activating agent such as N-hydroxysuccinimide improves the EDC-mediated coupling reaction, and the amino acid structure (alpha- or beta-) was shown to have an influence on the oligomerization efficiency, with beta-alanine polymerisation being more efficient. These findings are explained by reference to the reaction mechanism. (C) 2003 Published by Elsevier Ltd.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Journal or Publication Title:	EUROPEAN POLYMER JOURNAL
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
ISSN:	0014-3057
Date:	August 2003
Volume:	39
Number:	8
Number of Pages:	7
Page Range:	pp. 1559-1565
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/9495

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