Investigation of the effects of various parameters on the synthesis of oligopeptides in aqueous solution
UNSPECIFIED. (2003) Investigation of the effects of various parameters on the synthesis of oligopeptides in aqueous solution. EUROPEAN POLYMER JOURNAL, 39 (8). pp. 1559-1565. ISSN 0014-3057Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/S0014-3057(03)00050-8
Oligomerization efficiency of amino acids in aqueous solution has been compared under different conditions (temperature, activating agent, etc.) using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and 1,1'-carbonyldiimidazole (CDI) as coupling agents. Glycine (H2N-CH2-COOH) and alpha-alanine (H2N-CH(CH3)-COOH) were chosen as alpha-amino acids and beta-alanine (H2N-CH2-CH2-COOH) as the beta-amino acid. The coupling reaction between EDC and glycine was shown to occur but does not go to completion either at ambient temperature or at 70 degreesC. The presence of a carboxylic activating agent such as N-hydroxysuccinimide improves the EDC-mediated coupling reaction, and the amino acid structure (alpha- or beta-) was shown to have an influence on the oligomerization efficiency, with beta-alanine polymerisation being more efficient. These findings are explained by reference to the reaction mechanism. (C) 2003 Published by Elsevier Ltd.
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry|
|Journal or Publication Title:||EUROPEAN POLYMER JOURNAL|
|Publisher:||PERGAMON-ELSEVIER SCIENCE LTD|
|Official Date:||August 2003|
|Number of Pages:||7|
|Page Range:||pp. 1559-1565|
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