UNSPECIFIED (2003) IL-1 beta-dependent activation of NF-kappa B mediates PGE(2) release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase. FEBS LETTERS, 547 (1-3). pp. 75-79. ISSN 0014-5793

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Abstract

Prostaglandin (PG) E-2 release is induced in pulmonary A549 cells by the NF-kappaB-activating stimuli interleukin-1beta (IL-1beta) and phorbol 12-myristate 13-acetate (PMA). Adenoviral over-expression of IkappaBalphaDeltaN, a dominant NF-kappaB inhibitor, prevents NF-kappaB-dependent transcription and was used to qualify the role of NF-kappaB in the release of PGE(2). IkappaBalphaDeltaN repressed IL-1beta-induced, but not PMA-induced, cycloxygenase-2 (COX-2) and microsomal prostaglandin E synthase (mPGES) expression. These data conclusively demonstrate a substantial role for NF-kappabeta in the co-ordinate induction of COX-2, mPGES and in the corresponding release of PGE(2) by IL-1beta. However, other pathways are primarily responsible for PGE(2) release induced by PMA. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology
Journal or Publication Title:	FEBS LETTERS
Publisher:	ELSEVIER SCIENCE BV
ISSN:	0014-5793
Date:	17 July 2003
Volume:	547
Number:	1-3
Number of Pages:	5
Page Range:	pp. 75-79
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/9513

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