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Non-invasive diagnosis of pancreatic cancer through detection of volatile organic compounds in urine
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Arasaradnam, Ramesh P., Wicaksono, Alfian, O’Brien, Harrison, Kocher, Hemant M., Covington, James A. and Crnogorac-Jurcevic, Tatjana (2018) Non-invasive diagnosis of pancreatic cancer through detection of volatile organic compounds in urine. Gastroenterology, 154 (3). 485-487.e1. doi:10.1053/j.gastro.2017.09.054 ISSN 0016-5085.
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WRAP-non-invasive-diagnosis-pancreatic-cancer-through-detection-Covington-2017.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (609Kb) | Preview |
Official URL: http://dx.doi.org/10.1053/j.gastro.2017.09.054
Abstract
With its incidence approaching mortality, and with >300,000 new cases diagnosed worldwide in 2013, pancreatic ductal adenocarcinoma (PDAC) is currently the fourth leading cause of cancer-related death and predicted to become the second by 2030.1 More than 80% of patients with PDAC are diagnosed late,2 with locally invasive and/or metastatic disease, resulting in negligible 5-year survival. Thus, the quest for a simple, inexpensive, and noninvasive test to detect PDAC early, while it is still amenable to surgical resection, continues. Detection of volatile organic compounds (VOCs) has come to the fore offering a novel approach for the detection of disease. It uses the odors that emanate from urine, breath, and feces and is akin to canine “sniffing.” These compounds are metabolic products and/or consequence of bacterial dysbiosis produced by the disease state.3, 4 We thus postulate that either altered cellular physiology or even alteration in the microbial milieu in patients with PDAC will alter the individual’s metabolome profile, such that the resultant VOC patterns that are emitted provide a characteristic signature that can be detected.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||||||
| Library of Congress Subject Headings (LCSH): | Pancreas -- Cancer -- Diagnosis, Organic compounds | ||||||||
| Journal or Publication Title: | Gastroenterology | ||||||||
| Publisher: | W.B. Saunders Co. | ||||||||
| ISSN: | 0016-5085 | ||||||||
| Official Date: | February 2018 | ||||||||
| Dates: |
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| Volume: | 154 | ||||||||
| Number: | 3 | ||||||||
| Page Range: | 485-487.e1 | ||||||||
| DOI: | 10.1053/j.gastro.2017.09.054 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Date of first compliant deposit: | 21 November 2017 | ||||||||
| Date of first compliant Open Access: | 9 November 2018 | ||||||||
| RIOXX Funder/Project Grant: |
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