The Library
Synthesis of degradable poly(vinyl alcohol) by radical ring-opening copolymerization and ice recrystallization inhibition activity
Tools
Tools
Tools
Hedir, Guillaume, Stubbs, Christopher D., Aston, Phillip, Dove, Andrew P. and Gibson, Matthew I. (2017) Synthesis of degradable poly(vinyl alcohol) by radical ring-opening copolymerization and ice recrystallization inhibition activity. ACS Macro Letters, 6 (12). pp. 1404-1408. ISSN 2161-1653.
|
PDF
WRAP-synthesis-degradable-poly(vinylalcohol)-radical-ring-opening-copolymerization-Gibson-2017.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (2384Kb) | Preview |
|
![[img]](http://wrap.warwick.ac.uk/style/images/fileicons/application_pdf.png) |
PDF
WRAP-synthesis-degradable-poly-vinylalcohol-radical-ring-opening-copolymerization-Hedir-2017.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer. Download (3635Kb) |
Official URL: https://doi.org/10.1021/acsmacrolett.7b00905
Abstract
Poly(vinyl alcohol), PVA, is the most active synthetic mimic of antifreeze proteins and has extremely high ice recrystallization inhibition, IRI, activity. Addition of PVA to cellular cryopreservation solutions increases the number of recovered viable cells due to its potent IRI, but it is intrinsically non-degradable in vivo. Here we report the synthesis, characterization and IRI activity of PVA-containing degradable ester linkages. Vinyl chloroacetate, VClAc, was copolymerized with 2-methylene-1,3-dioxepane (MDO) which undergoes radical ring-opening polymerization to install main-chain ester units. The use of the chloroacetate monomer enabled selective deacetylation with retention of esters within the polymer backbone. Quantitative IRI assays revealed that the MDO content had to be finely tuned to retain IRI activity, with higher loadings (24 mol%) resulting in complete loss of IRI activity. These degradable materials will help translate PVA, which is non-toxic and biocompatible into a range of biomedical applications.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Divisions: | Other > Institute of Advanced Study Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||||
| Journal or Publication Title: | ACS Macro Letters | ||||||
| Publisher: | American Chemical Society | ||||||
| ISSN: | 2161-1653 | ||||||
| Official Date: | 1 December 2017 | ||||||
| Dates: |
|
||||||
| Volume: | 6 | ||||||
| Number: | 12 | ||||||
| Page Range: | pp. 1404-1408 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||
| Date of first compliant deposit: | 21 November 2017 | ||||||
| Date of first compliant Open Access: | 21 January 2019 |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
