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Supramolecular photoactivatable anticancer hydrogels
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Venkatesh, Venkatesh, Mishra, Narendra, Romero-Canelón, Isolda, Vernooij, Robbin, Shi, Huayun, Coverdale, James P. C., Habtemariam, Abraha, Verma, Sandeep and Sadler, P. J. (2017) Supramolecular photoactivatable anticancer hydrogels. Journal of the American Chemical Society, 139 (16). pp. 5656-5659. doi:10.1021/jacs.7b00186 ISSN 0002-7863.
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Official URL: http://dx.doi.org/10.1021/jacs.7b00186
Abstract
A photoactivatable dopamine-conjugated platinum(IV) anticancer complex (Pt-DA) has been incorporated into G-quadruplex G4K+ borate hydrogels by using borate ester linkages (Pt-G4K+B hydrogel). These were characterized by 11B NMR, attenuated total reflection Fourier transform infrared spectroscopy, circular dichroism, scanning electron microscopy and transmission electron microscopy. Microscopy investigations revealed the transformation of an extended fiber assembly into discrete flakes after incorporation of Pt-DA. Pt-DA showed photocytotoxicity against cisplatin-resistant A2780Cis human ovarian cancer cells (IC50 74 μM, blue light) with a photocytotoxic index <2, whereas Pt-G4K+B hydrogels exhibited more potent photocytotoxicity (IC50 3 μM, blue light) with a photocytotoxic index >5. Most notably, Pt-DA and Pt-G4K+B hydrogels show selective phototoxicity for cancer cells versus normal fibroblast cells (MRC5).
Item Type: | Journal Article | |||||||||||||||||||||
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Subjects: | Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | |||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Polymeric drug delivery systems, Colloids, Antineoplastic agents | |||||||||||||||||||||
Journal or Publication Title: | Journal of the American Chemical Society | |||||||||||||||||||||
Publisher: | American Chemical Society | |||||||||||||||||||||
ISSN: | 0002-7863 | |||||||||||||||||||||
Official Date: | 17 April 2017 | |||||||||||||||||||||
Dates: |
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Volume: | 139 | |||||||||||||||||||||
Number: | 16 | |||||||||||||||||||||
Page Range: | pp. 5656-5659 | |||||||||||||||||||||
DOI: | 10.1021/jacs.7b00186 | |||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||
Date of first compliant deposit: | 21 November 2017 | |||||||||||||||||||||
Date of first compliant Open Access: | 23 November 2017 | |||||||||||||||||||||
RIOXX Funder/Project Grant: |
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