UNSPECIFIED (2003) Slow frequency repetitive transcranial magnetic stimulation affects reaction times, but not priming effects, in a masked prime task. CLINICAL NEUROPHYSIOLOGY, 114 (7). pp. 1272-1277. ISSN 1388-2457

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Abstract

Objective: Slow frequency repetitive transcranial magnetic stimulation (rTMS) reduces motor cortex excitability, but it is unclear whether this has behavioural consequences in healthy subjects. Methods: We examined the effects of 1 Hz rTMS (train of 20 min; stimulus intensity 80% of active motor threshold) over left motor or left premotor cortex on performance in a visually cued choice reaction time task, using a 'masked prime' paradigm to assess whether rTMS might affect more automatic motor processes. Twelve healthy volunteers participated. Results: Motor cortex rTMS and, to a lesser extent, premotor cortex rTMS resulted in a slowing of right (stimulated) hand responses, but not of left (unstimulated) hand responses. In a control experiment, rTMS of the left somatosensory cortex did not lead to slower right hand responses. Discussion: We conclude that long trains of low intensity 1 Hz rTMS over the motor or premotor cortex can have subtle behavioural consequences outlasting the stimulation. rTMS did not affect the modulation of reaction times by subliminal primes, suggesting that priming effects triggered by subliminal primes are not generated at the level of motor or pre-motor cortex. (C) 2003 International Federation of Clinical Neurophysiology. Published by Elsevier Science Ireland Ltd. All rights reserved.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Journal or Publication Title:	CLINICAL NEUROPHYSIOLOGY
Publisher:	ELSEVIER SCI IRELAND LTD
ISSN:	1388-2457
Date:	July 2003
Volume:	114
Number:	7
Number of Pages:	6
Page Range:	pp. 1272-1277
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/9538

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