UNSPECIFIED (2003) Rosacea: A cutaneous marker of Helicobacter pylori infection? Results of a pilot study. ACTA DERMATO-VENEREOLOGICA, 83 (4). pp. 282-286. ISSN 0001-5555

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Abstract

Given the long purported anecdotal association between rosacea and gastrointestinal disease, the discovery that Helicobacter pylori causes gastritis and duodenal ulcer disease has led to a hypothesized role for this organism in the aetiology of rosacea. We conducted a case-series study of 49 patients to assess the potential association between severity of rosacea and direct and serological evidence of H. pylori infection. Patients were classified by severity into non-inflammatory erythematotelangiectatic or inflammatory/papulopustular rosacea and were tested for current H. pylori infection and evidence of previous exposure. Positive C-13-urea breath test and ELISA tests were more likely to be observed in patients with inflammatory rosacea, although not statistically significantly so (OR = 3.0, p = 0.15 and OR = 2.9, p = 0.16, respectively). However, the proportion of patients who tested positive in both assays (versus negative in at least one) was even higher in the inflammatory rosacea group and neared statistical significance (OR = 4.5, p = 0.06). This pilot study provides sufficient evidence suggestive of a positive association between the severity of rosacea and the presence of H. pylori to warrant further research.

Item Type:	Journal Article
Subjects:	R Medicine > RL Dermatology
Journal or Publication Title:	ACTA DERMATO-VENEREOLOGICA
Publisher:	TAYLOR & FRANCIS AS
ISSN:	0001-5555
Date:	2003
Volume:	83
Number:	4
Number of Pages:	5
Page Range:	pp. 282-286
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/9539

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