Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Wide variation in severe neonatal morbidity among very preterm infants in European regions

Tools
- Tools
+ Tools

Effective Perinatal Intensive Care in Europe (EPICE) Research Group (Including: Bonamy, A. K., Zeitlin, J., Piedvache, A., Maier, R. F., van Heijst, A., Varendi, H., Manktelow, B., Fenton, A., Mazela, J., Cuttini, M., Norman, M., Petrou, Stavros, Van Reempts, P., Barros, H. and Draper, E. S.). (2018) Wide variation in severe neonatal morbidity among very preterm infants in European regions. Archives of Disease in Childhood, 104 (1). F36-F45. doi:10.1136/archdischild-2017-313697

[img]
Preview
PDF
WRAP-wide-variation-severe-neonatal-morbidity-among-preterm-infants-European-regions-Petrou-2018.pdf - Published Version - Requires a PDF viewer.
Available under License Creative Commons: Attribution-Noncommercial 4.0.

Download (392Kb) | Preview
Official URL: http://dx.doi.org/10.1136/archdischild-2017-313697

Request Changes to record.

Abstract

Objective To investigate the variation in severe neonatal morbidity among very preterm (VPT) infants across European regions and whether morbidity rates are higher in regions with low compared with high mortality rates.

Design Area-based cohort study of all births before 32 weeks of gestational age.

Setting 16 regions in 11 European countries in 2011/2012.

Patients Survivors to discharge from neonatal care (n=6422).

Main outcome measures Severe neonatal morbidity was defined as intraventricular haemorrhage grades III and IV, cystic periventricular leukomalacia, surgical necrotizing enterocolitis and retinopathy of prematurity grades ≥3. A secondary outcome included severe bronchopulmonary dysplasia (BPD), data available in 14 regions. Common definitions for neonatal morbidities were established before data abstraction from medical records. Regional severe neonatal morbidity rates were correlated with regional in-hospital mortality rates for live births after adjustment on maternal and neonatal characteristics.

Results 10.6% of survivors had a severe neonatal morbidity without severe BPD (regional range 6.4%–23.5%) and 13.8% including severe BPD (regional range 10.0%–23.5%). Adjusted inhospital mortality was 13.7% (regional range 8.4%–18.8%). Differences between regions remained significant after consideration of maternal and neonatal characteristics (P<0.001) and severe neonatal morbidity rates were not correlated with mortality rates (P=0.50).

Conclusion Severe neonatal morbidity rates for VPT survivors varied widely across European regions and were independent of mortality rates.

Item Type: Journal Article
Subjects: R Medicine > RG Gynecology and obstetrics
R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Divisions: Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit
Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Newborn infants--Death, Newborn infants--Mortality--Europe, Perinatal death--Europe, Premature infants--Europe
Journal or Publication Title: Archives of Disease in Childhood
Publisher: BMJ
ISSN: 0003-9888
Official Date: 20 January 2018
Dates:
DateEvent
20 January 2018Available
27 November 2017Accepted
Volume: 104
Number: 1
Page Range: F36-F45
DOI: 10.1136/archdischild-2017-313697
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: Neonatal Networks for East Midlands and Yorkshire and Humber regions
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
259882Seventh Framework Programmehttp://dx.doi.org/10.13039/100011102
UNSPECIFIEDInstitut de veille sanitaire (France)‏ http://viaf.org/viaf/150141539
ANR-11-EQPX-0038 Agence Nationale de la Recherchehttp://dx.doi.org/10.13039/501100001665
UNSPECIFIEDMinisterstwo Nauki i Szkolnictwa Wyższegohttp://dx.doi.org/10.13039/501100004569
UNSPECIFIEDStockholms Läns Landstinghttp://dx.doi.org/10.13039/501100004348
UNSPECIFIEDKarolinska Universitetssjukhusethttp://viaf.org/viaf/135449868

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us