UNSPECIFIED. (2003) Seroepidemiology of measles in Addis Ababa, Ethiopia: implications for control through vaccination. EPIDEMIOLOGY AND INFECTION, 130 (3). pp. 507-519. ISSN 0950-2688

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Abstract

We undertook a representative survey of measles antibodies in Addis Ababa, Ethiopia 1994, to characterize immunity and transmission. Specific-antibody levels (IU/I) were determined by ELISA for 4654 sera from individuals aged 0-49 years (1805 < 15 years) collected by stratified household-cluster sampling. The proportion seronegative (<100 IU/l) was 20% (95% CI: 16-25) in children 9-59 months old, declining to 9% (7-12) in 5-9 year olds, 5% (4-7) in 10-14 year olds, and <1% in adults. The proportion of children (<15 years old) with low-level antibody (100-255 IU/l) was 8% (7-10). Vaccination and an absence of a history of measles illness were strongly associated with low-level antibody. History of measles vaccination in 9 months to 14-year-old children was similar to80%. We estimate a primary vaccine failure rate of 21% (12-34) and continued high measles incidence of 22 per 100 susceptibles (19-24) per annum. Our data support the introduction of campaign vaccination in the city in 1998, although higher routine vaccine coverage is required to sustain the impact. The implications of a high prevalence of low-level antibody are discussed.

Item Type:	Journal Article
Subjects:	R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine Q Science > QR Microbiology > QR355 Virology
Journal or Publication Title:	EPIDEMIOLOGY AND INFECTION
Publisher:	CAMBRIDGE UNIV PRESS
ISSN:	0950-2688
Date:	June 2003
Volume:	130
Number:	3
Number of Pages:	13
Page Range:	pp. 507-519
Identification Number:	10.1017/S0950268803008446
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/9572

Data sourced from Thomson Reuters' Web of Knowledge

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