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Seroepidemiology of measles in Addis Ababa, Ethiopia: implications for control through vaccination
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UNSPECIFIED (2003) Seroepidemiology of measles in Addis Ababa, Ethiopia: implications for control through vaccination. EPIDEMIOLOGY AND INFECTION, 130 (3). pp. 507-519. doi:10.1017/S0950268803008446
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Official URL: http://dx.doi.org/10.1017/S0950268803008446
Abstract
We undertook a representative survey of measles antibodies in Addis Ababa, Ethiopia 1994, to characterize immunity and transmission. Specific-antibody levels (IU/I) were determined by ELISA for 4654 sera from individuals aged 0-49 years (1805 < 15 years) collected by stratified household-cluster sampling. The proportion seronegative (<100 IU/l) was 20% (95% CI: 16-25) in children 9-59 months old, declining to 9% (7-12) in 5-9 year olds, 5% (4-7) in 10-14 year olds, and <1% in adults. The proportion of children (<15 years old) with low-level antibody (100-255 IU/l) was 8% (7-10). Vaccination and an absence of a history of measles illness were strongly associated with low-level antibody. History of measles vaccination in 9 months to 14-year-old children was similar to80%. We estimate a primary vaccine failure rate of 21% (12-34) and continued high measles incidence of 22 per 100 susceptibles (19-24) per annum. Our data support the introduction of campaign vaccination in the city in 1998, although higher routine vaccine coverage is required to sustain the impact. The implications of a high prevalence of low-level antibody are discussed.
| Item Type: | Journal Article | ||||
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| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine Q Science > QR Microbiology > QR355 Virology |
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| Journal or Publication Title: | EPIDEMIOLOGY AND INFECTION | ||||
| Publisher: | CAMBRIDGE UNIV PRESS | ||||
| ISSN: | 0950-2688 | ||||
| Official Date: | June 2003 | ||||
| Dates: |
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| Volume: | 130 | ||||
| Number: | 3 | ||||
| Number of Pages: | 13 | ||||
| Page Range: | pp. 507-519 | ||||
| DOI: | 10.1017/S0950268803008446 | ||||
| Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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