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Influence of block copolymerization on the antifreeze protein mimetic ice recrystallization inhibition activity of poly(vinyl alcohol)

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Congdon, Thomas R., Notman, Rebecca and Gibson, Matthew I. (2016) Influence of block copolymerization on the antifreeze protein mimetic ice recrystallization inhibition activity of poly(vinyl alcohol). Biomacromolecules, 17 (9). pp. 3033-3039. doi:10.1021/acs.biomac.6b00915

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Official URL: https://doi.org/10.1021/acs.biomac.6b00915

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Abstract

Antifreeze (glyco) proteins are produced by many cold-acclimatized species to enable them to survive subzero temperatures. These proteins have multiple macroscopic effects on ice crystal growth which makes them appealing for low-temperature applications—from cellular cryopreservation to food storage. Poly(vinyl alcohol) has remarkable ice recrystallization inhibition activity, but its mode of action is uncertain as is the extent at which it can be incorporated into other high-order structures. Here the synthesis and characterization of well-defined block copolymers containing poly(vinyl alcohol) and poly(vinylpyrrolidone) by RAFT/MADIX polymerization is reported, as new antifreeze protein mimetics. The effect of adding a large second hydrophilic block is studied across a range of compositions, and it is found to be a passive component in ice recrystallization inhibition assays, enabling retention of all activity. In the extreme case, a block copolymer with only 10% poly(vinyl alcohol) was found to retain all activity, where statistical copolymers of PVA lose all activity with very minor changes to composition. These findings present a new method to increase the complexity of antifreeze protein mimetic materials, while retaining activity, and also to help understand the underlying mechanisms of action.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Q Science > QP Physiology
T Technology > TP Chemical technology
Divisions: Faculty of Science > Chemistry
Faculty of Medicine > Warwick Medical School
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Antifreeze proteins , Block copolymers , Polyvinyl alcohol , Polymerization
Journal or Publication Title: Biomacromolecules
Publisher: American Chemical Society (ACS)
ISSN: 1526-4602
Official Date: 12 August 2016
Dates:
DateEvent
12 August 2016Published
12 September 2016Available
31 July 2016Accepted
Date of first compliant deposit: 26 October 2020
Volume: 17
Number: 9
Page Range: pp. 3033-3039
DOI: 10.1021/acs.biomac.6b00915
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
RPG 144Leverhulme Trusthttp://dx.doi.org/10.13039/501100000275
CRYOMAT 638661European Research Councilhttp://dx.doi.org/10.13039/501100000781
UNSPECIFIEDRoyal Societyhttp://dx.doi.org/10.13039/501100000288
Related URLs:
  • http://pubs.acs.org/doi/pdf/10.1021/acs....
  • http://pubs.acs.org/doi/pdf/10.1021/acs....
  • http://pubs.acs.org/page/policy/authorch...

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