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Influence of block copolymerization on the antifreeze protein mimetic ice recrystallization inhibition activity of poly(vinyl alcohol)
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Congdon, Thomas R., Notman, Rebecca and Gibson, Matthew I. (2016) Influence of block copolymerization on the antifreeze protein mimetic ice recrystallization inhibition activity of poly(vinyl alcohol). Biomacromolecules, 17 (9). pp. 3033-3039. doi:10.1021/acs.biomac.6b00915
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WRAP-Influence-block-copolymerization-antifreeze-protein-Gibson-2016.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (2474Kb) | Preview |
Official URL: https://doi.org/10.1021/acs.biomac.6b00915
Abstract
Antifreeze (glyco) proteins are produced by many cold-acclimatized species to enable them to survive subzero temperatures. These proteins have multiple macroscopic effects on ice crystal growth which makes them appealing for low-temperature applications—from cellular cryopreservation to food storage. Poly(vinyl alcohol) has remarkable ice recrystallization inhibition activity, but its mode of action is uncertain as is the extent at which it can be incorporated into other high-order structures. Here the synthesis and characterization of well-defined block copolymers containing poly(vinyl alcohol) and poly(vinylpyrrolidone) by RAFT/MADIX polymerization is reported, as new antifreeze protein mimetics. The effect of adding a large second hydrophilic block is studied across a range of compositions, and it is found to be a passive component in ice recrystallization inhibition assays, enabling retention of all activity. In the extreme case, a block copolymer with only 10% poly(vinyl alcohol) was found to retain all activity, where statistical copolymers of PVA lose all activity with very minor changes to composition. These findings present a new method to increase the complexity of antifreeze protein mimetic materials, while retaining activity, and also to help understand the underlying mechanisms of action.
| Item Type: | Journal Article | ||||||||||||
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| Subjects: | Q Science > QD Chemistry Q Science > QP Physiology T Technology > TP Chemical technology |
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| Divisions: | Faculty of Science > Chemistry Faculty of Medicine > Warwick Medical School |
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| SWORD Depositor: | Library Publications Router | ||||||||||||
| Library of Congress Subject Headings (LCSH): | Antifreeze proteins , Block copolymers , Polyvinyl alcohol , Polymerization | ||||||||||||
| Journal or Publication Title: | Biomacromolecules | ||||||||||||
| Publisher: | American Chemical Society (ACS) | ||||||||||||
| ISSN: | 1526-4602 | ||||||||||||
| Official Date: | 12 August 2016 | ||||||||||||
| Dates: |
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| Volume: | 17 | ||||||||||||
| Number: | 9 | ||||||||||||
| Page Range: | pp. 3033-3039 | ||||||||||||
| DOI: | 10.1021/acs.biomac.6b00915 | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | Published | ||||||||||||
| Access rights to Published version: | Open Access | ||||||||||||
| RIOXX Funder/Project Grant: |
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