The Library
Cannabis use and hypomania in young people : a prospective analysis
Tools
Tools
Tools
Marwaha, Steven, Winsper, Catherine, Bebbington, Paul and Smith, Daniel (2018) Cannabis use and hypomania in young people : a prospective analysis. Schizophrenia Bulletin, 44 (6). pp. 1267-1274. doi:10.1093/schbul/sbx158 ISSN 0586-7614.
|
PDF
WRAP-cannabis-use-hypomania-young people-prospective-analysis-Marwaha-2017.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1227Kb) | Preview |
Official URL: http://dx.doi.org/10.1093/schbul/sbx158
Abstract
Cannabis use in young people is common and associated with psychiatric disorders. However, the prospective link between cannabis use and bipolar disorder symptoms has rarely been investigated. The study hypothesis was that adolescent cannabis use is associated with hypomania in early adulthood via several potential etiological pathways. Methods: Data were used from the Avon Longitudinal Study of Parents and Children, a UK birth cohort study. The prospective link between cannabis use at age 17 and hypomania at age 22–23 years was tested using regression analysis, adjusted for gender, early environmental risk factors, alcohol and drug use, and depression and psychotic symptoms at age 18 years. Path analysis examined direct and indirect effects of the link and whether gender, childhood family adversity, or childhood abuse are associated with hypomania via an increased risk of cannabis use. Results: Data were available on 3370 participants. Cannabis use at least 2–3 times weekly was associated with later hypomania (OR = 2.21, 95% CI = 1.49–3.28) after adjustment. There was a dose– response relationship (any use vs weekly). Cannabis use mediated the association of both childhood sexual abuse and hypomania, and male gender and hypomania. The cannabis use-hypomania link was not mediated by depression or psychotic symptoms. Conclusions: Adolescent cannabis use may be an independent risk factor for future hypomania, and the nature of the association suggests a potential causal link. Cannabis use mediates the link between childhood abuse and future hypomania. As such it might be a useful target for indicated prevention of hypomania.
| Item Type: | Journal Article | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine | ||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||||||||||
| Library of Congress Subject Headings (LCSH): | Cannabis -- Health aspects, Cannabis -- Physiological effect, Hypomania, Manic-depressive illness, Youth -- Drug use | ||||||||||||
| Journal or Publication Title: | Schizophrenia Bulletin | ||||||||||||
| Publisher: | Oxford University Press | ||||||||||||
| ISSN: | 0586-7614 | ||||||||||||
| Official Date: | 17 October 2018 | ||||||||||||
| Dates: |
|
||||||||||||
| Volume: | 44 | ||||||||||||
| Number: | 6 | ||||||||||||
| Page Range: | pp. 1267-1274 | ||||||||||||
| DOI: | 10.1093/schbul/sbx158 | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | Published | ||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||
| Date of first compliant deposit: | 4 December 2017 | ||||||||||||
| Date of first compliant Open Access: | 5 December 2017 | ||||||||||||
| RIOXX Funder/Project Grant: |
|
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
