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Cannabis use and hypomania in young people : a prospective analysis

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Marwaha, Steven, Winsper, Catherine, Bebbington, Paul and Smith, Daniel (2018) Cannabis use and hypomania in young people : a prospective analysis. Schizophrenia Bulletin, 44 (6). pp. 1267-1274. doi:10.1093/schbul/sbx158 ISSN 0586-7614.

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Official URL: http://dx.doi.org/10.1093/schbul/sbx158

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Abstract

Cannabis use in young people is common and associated with psychiatric disorders. However, the prospective link between cannabis use and bipolar disorder symptoms has rarely been investigated. The study hypothesis was that adolescent cannabis use is associated with hypomania in early adulthood via several potential etiological pathways. Methods: Data were used from the Avon Longitudinal Study of Parents and Children, a UK birth cohort study. The prospective link between cannabis use at age 17 and hypomania at age 22–23 years was tested using regression analysis, adjusted for gender, early environmental risk factors, alcohol and drug use, and depression and psychotic symptoms at age 18 years. Path analysis examined direct and indirect effects of the link and whether gender, childhood family adversity, or childhood abuse are associated with hypomania via an increased risk of cannabis use. Results: Data were available on 3370 participants. Cannabis use at least 2–3 times weekly was associated with later hypomania (OR = 2.21, 95% CI = 1.49–3.28) after adjustment. There was a dose– response relationship (any use vs weekly). Cannabis use mediated the association of both childhood sexual abuse and hypomania, and male gender and hypomania. The cannabis use-hypomania link was not mediated by depression or psychotic symptoms. Conclusions: Adolescent cannabis use may be an independent risk factor for future hypomania, and the nature of the association suggests a potential causal link. Cannabis use mediates the link between childhood abuse and future hypomania. As such it might be a useful target for indicated prevention of hypomania.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Cannabis -- Health aspects, Cannabis -- Physiological effect, Hypomania, Manic-depressive illness, Youth -- Drug use
Journal or Publication Title: Schizophrenia Bulletin
Publisher: Oxford University Press
ISSN: 0586-7614
Official Date: 17 October 2018
Dates:
DateEvent
17 October 2018Published
28 November 2017Available
10 October 2017Accepted
Volume: 44
Number: 6
Page Range: pp. 1267-1274
DOI: 10.1093/schbul/sbx158
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 4 December 2017
Date of first compliant Open Access: 5 December 2017
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIEDMedical Research Council (MRC)http://dx.doi.org/10.13039/501100000265
102215/2/13/2Wellcomehttp://dx.doi.org/10.13039/100010269
UNSPECIFIEDUniversity of Bristolhttp://dx.doi.org/10.13039/501100000883

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