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Millennia of genomic stability within the invasive Para C Lineage of Salmonella enterica
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Zhou, Zhemin, Lundstrøm, Inge, Tran-Dien, Alicia, Duchêne, Sebastián, Alikhan, Nabil-Fareed, Sergeant, Martin J., Langridge, Gemma, Fotakis, Anna K., Nair, Satheesh, Stenøien, Hans K., Hamre, Stian S., Casjens, Sherwood, Christophersen, Axel, Quince, Christopher, Thomson, Nicholas R., Weill, François-Xavier, Ho, Simon Y. W., Gilbert, M. Thomas P. and Achtman, Mark (2017) Millennia of genomic stability within the invasive Para C Lineage of Salmonella enterica. Working Paper. BioRxiv: Cold Spring Harbour.
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Official URL: http://dx.doi.org/10.1101/105759
Abstract
Salmonella enterica serovar Paratyphi C is the causative agent of enteric (paratyphoid) fever. While today a potentially lethal infection of humans that occurs in Africa and Asia, early 20th century observations in Eastern Europe suggest it may once have had a wider-ranging impact on human societies. We recovered a draft Paratyphi C genome from the 800-year-old skeleton of a young woman in Trondheim, Norway, who likely died of enteric fever. Analysis of this genome against a new, significantly expanded database of related modern genomes demonstrated that Paratyphi C is descended from the ancestors of swine pathogens, serovars Choleraesuis and Typhisuis, together forming the Para C Lineage. Our results indicate that Paratyphi C has been a pathogen of humans for at least 1,000 years, and may have evolved after zoonotic transfer from swine during the Neolithic period.
Item Type: | Working or Discussion Paper (Working Paper) | |||||||||||||||
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Subjects: | Q Science > QR Microbiology | |||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Typhoid fever -- Genetic aspects -- History, Typhoid fever -- Trondheim (Norway) -- 13th century | |||||||||||||||
Journal or Publication Title: | biorxiv | |||||||||||||||
Publisher: | Cold Spring Harbour | |||||||||||||||
Place of Publication: | BioRxiv | |||||||||||||||
Book Title: | Millennia of genomic stability within the invasive Para C Lineage of Salmonella enterica | |||||||||||||||
Official Date: | 14 February 2017 | |||||||||||||||
Dates: |
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Number: | 105759 | |||||||||||||||
DOI: | 10.1101/105759 | |||||||||||||||
Institution: | University of Warwick | |||||||||||||||
Status: | Not Peer Reviewed | |||||||||||||||
Publication Status: | Published | |||||||||||||||
RIOXX Funder/Project Grant: |
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