UNSPECIFIED (2003) VegT induces endoderm by a self-limiting mechanism and by changing the competence of cells to respond to TGF-beta signals. DEVELOPMENTAL BIOLOGY, 258 (2). pp. 454-463. ISSN 0012-1606

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Abstract

The maternal determinant VegT is required for both endoderm, and mesoderm formation by the Xenopus embryo. An important downstream mediator of VegT action is Xsox17, which has been proposed to be induced in cell-autonomous, then signal-dependent phases. We show that Xsox17 is a direct VegT target, but that direct induction of Xsox17 by VegT is rapidly inhibited. This inhibition is relieved by TGF- beta signalling, to which the future endoderm cell is sensitised by VegT, resulting in the observed dependence on cell contact for maintained Xsox17 expression. We propose that this change in regulation is a consequence of a VegT-induced repressor, inhibiting direct induction of early endoderm markers by VegT, and contributing to the formation of the boundary of the endodermal domain. (C) 2003 Elsevier Science (USA). All rights reserved.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH301 Biology
Journal or Publication Title:	DEVELOPMENTAL BIOLOGY
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
ISSN:	0012-1606
Date:	15 June 2003
Volume:	258
Number:	2
Number of Pages:	10
Page Range:	pp. 454-463
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/9619

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