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A semi-automated system based on level sets and invariant spatial interrelation shape features for Caenorhabditis elegans phenotypes

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Abdelsamea, Mohammed M. (2016) A semi-automated system based on level sets and invariant spatial interrelation shape features for Caenorhabditis elegans phenotypes. Journal of Visual Communication and Image Representation, 41 . pp. 314-323. doi:10.1016/j.jvcir.2016.10.011

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Official URL: http://dx.doi.org/10.1016/j.jvcir.2016.10.011

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Abstract

Caenorhabditis elegans shares several molecular and physiological homologies with humans and thus plays a key role in studying biological processes. As a consequence, much progress has been made in automating the analysis of C. elegans. However, there is still a strong need to achieve more progress in automating the analysis of static images of adult worms. In this paper, a three-phase semi-automated system has been proposed. As a first phase, a novel segmentation framework, based on variational level sets and local pressure force function, has been introduced to handle effectively images corrupted with intensity inhomogeneity. Then, a set of robust invariant symbolic features for high-throughput screening of image-based C. elegans phenotypes are extracted. Finally, a classification model is applied to discriminate between the different subsets. The proposed system demonstrates its effectiveness in measuring morphological phenotypes in individual worms of C. elegans.

Item Type: Journal Article
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology
Faculty of Medicine > Warwick Medical School > Biomedical Sciences
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: Journal of Visual Communication and Image Representation
Publisher: Academic Press Inc Elsevier Science
ISSN: 1047-3203
Official Date: November 2016
Dates:
DateEvent
November 2016Published
19 October 2016Available
19 October 2016Accepted
Volume: 41
Page Range: pp. 314-323
DOI: 10.1016/j.jvcir.2016.10.011
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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