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Neurocognitive outcome in young adults born late-preterm
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Heinonen, Kati, Lahti, Jari, Sammallahti, Sara, Wolke, Dieter, Lano, Aulikki, Andersson, Sture, Pesonen, Anu-Katriina, Eriksson, Johan G., Kajantie, Eero and Raikkonen, Katri (2018) Neurocognitive outcome in young adults born late-preterm. Developmental Medicine & Child Neurology, 60 (3). pp. 267-274. doi:10.1111/dmcn.13616 ISSN 0012-1622.
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Official URL: http://doi.org/10.1111/dmcn.13616
Abstract
Aim
This study examined whether late-preterm birth (34+0 to 36+6wks+d gestational age) was associated with neurocognitive deficit in young adulthood, and whether small for gestational age (SGA) birth amplified any adversity.
Method
Participants derived from the prospective regional cohort study, the Arvo Ylppö Longitudinal Study (n=786; 398 females, 388 males) (mean age 25y 4mo, SD 8mo), born 1985 to 1986 late-preterm (n=119; 21 SGA, <−2 SD) and at term (37+0 to 41+6wks+d; n=667; 28 SGA) underwent tests of intelligence, executive functioning, attention, and memory, and reported their education.
Results
Those born late-preterm scored −3.71 (95% confidence interval [CI] −6.71 to −0.72) and −3.11 (95% CI −6.01 to −0.22) points lower on Full-scale and Verbal IQ than peers born at term. Compared with those born at term and appropriate for gestational age (≥−2 to <2 SD) Full-scale, Verbal, and Performance IQ scores of those born late-preterm and SGA were −9.45 to −11.84 points lower. After adjustments, differences were rendered non-significant, except that scores in Full-scale and Performance IQ remained lower among those born late-preterm and SGA.
Interpretation
Late-preterm birth, per se, may not increase the risk of poorer neurocognitive functioning in adulthood. But the double burden of being born late-preterm and SGA seems to increase this risk.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||
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Subjects: | R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services | ||||||||||||||||||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Psychology | ||||||||||||||||||||||||||||||||||||
SWORD Depositor: | Library Publications Router | ||||||||||||||||||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Premature infants, Young adults -- Psychology | ||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | Developmental Medicine & Child Neurology | ||||||||||||||||||||||||||||||||||||
Publisher: | Wiley-Blackwell | ||||||||||||||||||||||||||||||||||||
ISSN: | 0012-1622 | ||||||||||||||||||||||||||||||||||||
Official Date: | March 2018 | ||||||||||||||||||||||||||||||||||||
Dates: |
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Volume: | 60 | ||||||||||||||||||||||||||||||||||||
Number: | 3 | ||||||||||||||||||||||||||||||||||||
Page Range: | pp. 267-274 | ||||||||||||||||||||||||||||||||||||
DOI: | 10.1111/dmcn.13616 | ||||||||||||||||||||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||||||||||||||||||||
Date of first compliant deposit: | 12 January 2018 | ||||||||||||||||||||||||||||||||||||
Date of first compliant Open Access: | 27 November 2018 | ||||||||||||||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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