The involvement of progesterone in the onset of human labour
UNSPECIFIED (2003) The involvement of progesterone in the onset of human labour. European Journal of Obstetrics, Gynecology and Reproductive Biology, 108 (2). pp. 177-181. ISSN 0301-2115Full text not available from this repository.
Progesterone is essential for the maintenance of pregnancy, and acts to promote uterine quiescence. In many species progesterone levels fall prior to the onset of tabour but no fall has been observed in humans. The concept of 'functional' progesterone withdrawal in association with tabour has been proposed and a number of mechanisms have been suggested. Recent potential mechanisms of functional withdrawal include changes in progesterone receptor (PR) isoforms, regulation of PR responsive genes through nuclear factor kappaB (NF-kappaB) promoter sites and the non-genomic effects of progesterone or its metabolites. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RG Gynecology and obstetrics|
|Journal or Publication Title:||European Journal of Obstetrics, Gynecology and Reproductive Biology|
|Publisher:||Elsevier Ireland Ltd.|
|Date:||10 June 2003|
|Number of Pages:||5|
|Page Range:||pp. 177-181|
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