Alberti, Fabrizio, Foster, Gary D. and Bailey, Andy M. (2017) Natural products from filamentous fungi and production by heterologous expression. Applied Microbiology and Biotechnology, 101 (2). pp. 493-500. doi:10.1007/s00253-016-8034-2 ISSN 0175-7598.

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Abstract

Filamentous fungi represent an incredibly rich and rather overlooked reservoir of natural products, which often show potent bioactivity and find applications in different fields. Increasing the naturally low yields of bioactive metabolites within their host producers can be problematic, and yield improvement is further hampered by such fungi often being genetic intractable or having demanding culturing conditions. Additionally, total synthesis does not always represent a cost-effective approach for producing bioactive fungal-inspired metabolites, especially when pursuing assembly of compounds with complex chemistry. This review aims at providing insights into heterologous production of secondary metabolites from filamentous fungi, which has been established as a potent system for the biosynthesis of bioactive compounds. Numerous advantages are associated with this technique, such as the availability of tools that allow enhanced production yields and directing biosynthesis towards analogues of the naturally occurring metabolite. Furthermore, a choice of hosts is available for heterologous expression, going from model unicellular organisms to well-characterised filamentous fungi, which has also been shown to allow the study of biosynthesis of complex secondary metabolites. Looking to the future, fungi are likely to continue to play a substantial role as sources of new pharmaceuticals and agrochemicals—either as producers of novel natural products or indeed as platforms to generate new compounds through synthetic biology.

Item Type:	Journal Article
Subjects:	Q Science > QK Botany
Divisions:	Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH):	Filamentous fungi -- Biotechnology, Natural products, Metabolites -- Biosynthesis, Bioactive compounds -- Biosynthesis
Journal or Publication Title:	Applied Microbiology and Biotechnology
Publisher:	Springer
ISSN:	0175-7598
Official Date:	January 2017
Dates:	Date Event January 2017 Published 13 December 2016 Available 25 November 2016 Accepted 1 September 2016 Submitted
Volume:	101
Number:	2
Page Range:	pp. 493-500
DOI:	10.1007/s00253-016-8034-2
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)

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