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Probing the dynamic nature of self-assembling cyclic peptide-polymer nanotubes in solution and in mammalian cells
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Rho, Julia Y., Brendel, Johannes C., MacFarlane, Liam R., Mansfield, Edward D. H., Peltier, Raoul, Rogers, Sarah, Hartlieb, Matthias and Perrier, Sébastien (2017) Probing the dynamic nature of self-assembling cyclic peptide-polymer nanotubes in solution and in mammalian cells. Advanced Functional Materials . 1704569. doi:10.1002/adfm.201704569
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WRAP-probing-dynamic-nature-self-assembling-cyclic-peptide-polymer-nanotubes-Perrier-2017.pdf - Accepted Version - Requires a PDF viewer. Download (3166Kb) | Preview |
Official URL: http://dx.doi.org/10.1002/adfm.201704569
Abstract
Self-assembling cyclic peptide–polymer nanotubes have emerged as a fascinating supramolecular system, well suited for a diverse range of biomedical applications. Due to their well-defined diameter, tunable peptide anatomy, and ability to disassemble in situ, they have been investigated as promising materials for numerous applications including biosensors, antimicrobials, and drug delivery. Despite this continuous effort, the underlying mechanisms of assembly and disassembly are still not fully understood. In particular, the exchange of units between individual assembled nanotubes has been overlooked so far, despite its knowledge being essential for understanding their behavior in different environments. To investigate the dynamic nature of these systems, cyclic peptide–polymer nanotubes are synthesized, conjugated with complementary dyes, which undergo a Förster resonance energy transfer (FRET) in close proximity. Model conjugates enable to demonstrate not only that their self-assembly is highly dynamic and not kinetically trapped, but also that the self-assembly of the conjugates is strongly influenced by both solvent and concentration. Additionally, the versatility of the FRET system allows studying the dynamic exchange of these systems in mammalian cells in vitro using confocal microscopy, demonstrating the exchange of subunits between assembled nanotubes in the highly complex environment of a cell.
| Item Type: | Journal Article | |||||||||||||||||||||
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| Subjects: | Q Science > QD Chemistry | |||||||||||||||||||||
| Divisions: | Faculty of Science > Chemistry | |||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Self-assembly (Chemistry), Nanotubes, Cyclic peptides, Biomedical materials | |||||||||||||||||||||
| Journal or Publication Title: | Advanced Functional Materials | |||||||||||||||||||||
| Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | |||||||||||||||||||||
| ISSN: | 1616-301X | |||||||||||||||||||||
| Official Date: | 7 November 2017 | |||||||||||||||||||||
| Dates: |
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| Date of first compliant deposit: | 19 December 2017 | |||||||||||||||||||||
| Article Number: | 1704569 | |||||||||||||||||||||
| DOI: | 10.1002/adfm.201704569 | |||||||||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||||||||
| Publication Status: | Published | |||||||||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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