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Probing the dynamic nature of self-assembling cyclic peptide-polymer nanotubes in solution and in mammalian cells

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Rho, Julia Y., Brendel, Johannes C., MacFarlane, Liam R., Mansfield, Edward D. H., Peltier, Raoul, Rogers, Sarah, Hartlieb, Matthias and Perrier, Sébastien (2018) Probing the dynamic nature of self-assembling cyclic peptide-polymer nanotubes in solution and in mammalian cells. Advanced Functional Materials, 28 (24). 1704569. doi:10.1002/adfm.201704569

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Official URL: http://dx.doi.org/10.1002/adfm.201704569

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Abstract

Self-assembling cyclic peptide–polymer nanotubes have emerged as a fascinating supramolecular system, well suited for a diverse range of biomedical applications. Due to their well-defined diameter, tunable peptide anatomy, and ability to disassemble in situ, they have been investigated as promising materials for numerous applications including biosensors, antimicrobials, and drug delivery. Despite this continuous effort, the underlying mechanisms of assembly and disassembly are still not fully understood. In particular, the exchange of units between individual assembled nanotubes has been overlooked so far, despite its knowledge being essential for understanding their behavior in different environments. To investigate the dynamic nature of these systems, cyclic peptide–polymer nanotubes are synthesized, conjugated with complementary dyes, which undergo a Förster resonance energy transfer (FRET) in close proximity. Model conjugates enable to demonstrate not only that their self-assembly is highly dynamic and not kinetically trapped, but also that the self-assembly of the conjugates is strongly influenced by both solvent and concentration. Additionally, the versatility of the FRET system allows studying the dynamic exchange of these systems in mammalian cells in vitro using confocal microscopy, demonstrating the exchange of subunits between assembled nanotubes in the highly complex environment of a cell.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH): Self-assembly (Chemistry), Nanotubes, Cyclic peptides, Biomedical materials
Journal or Publication Title: Advanced Functional Materials
Publisher: Wiley - V C H Verlag GmbH & Co. KGaA
ISSN: 1616-301X
Official Date: 13 June 2018
Dates:
DateEvent
13 June 2018Published
7 November 2017Available
7 November 2017Accepted
Volume: 28
Number: 24
Article Number: 1704569
DOI: 10.1002/adfm.201704569
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
Wolfson Research Merit Award (WM130055)Royal Societyhttp://dx.doi.org/10.13039/501100000288
UNSPECIFIEDMonash-Warwick AllianceUNSPECIFIED
TUSUPO 647106H2020 European Research Councilhttp://dx.doi.org/10.13039/100010663
HA 7725/1-1Deutsche Forschungsgemeinschafthttp://dx.doi.org/10.13039/501100001659
BR 4905/1-1Deutsche Forschungsgemeinschafthttp://dx.doi.org/10.13039/501100001659
BR 4905/2-1Deutsche Forschungsgemeinschafthttp://dx.doi.org/10.13039/501100001659

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