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Circadian rhythms in visual responsiveness in the behaviorally arrhythmic drosophila clock mutant ClkJrk
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Nippe, Olivia M., Wade, Alex R., Elliott, Christopher J. H. and Chawla, Sangeeta (2017) Circadian rhythms in visual responsiveness in the behaviorally arrhythmic drosophila clock mutant ClkJrk. Journal of Biological Rhythms, 32 (6). pp. 583-592. doi:10.1177/0748730417735397 ISSN 0748-7304.
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Official URL: http://dx.doi.org/10.1177/0748730417735397
Abstract
An organism’s biological day is characterized by a pattern of anticipatory physiological and behavioral changes that are governed by circadian clocks to align with the 24-h cycling environment. Here, we used flash electroretinograms (ERGs) and steady-state visually evoked potentials (SSVEPs) to examine how visual responsiveness in wild-type Drosophila melanogaster and the circadian clock mutant ClkJrk varies over circadian time. We show that the ERG parameters of wild-type flies vary over the circadian day, with a higher luminance response during the subjective night. The SSVEP response that assesses contrast sensitivity also showed a time-of-day dependence, including 2 prominent peaks within a 24-h period and a maximal response at the end of the subjective day, indicating a tradeoff between luminance and contrast sensitivity. Moreover, the behaviorally arrhythmic ClkJrk mutants maintained a circadian profile in both luminance and contrast sensitivity, but unlike the wild-types, which show bimodal profiles in their visual response, ClkJrk flies show a weakening of the bimodal character, with visual responsiveness tending to peak once a day. We conclude that the ClkJrk mutation mainly affects 1 of 2 functionally coupled oscillators and that the visual system is partially separated from the locomotor circadian circuits that drive bouts of morning and evening activity. As light exposure is a major mechanism for entrainment, our work suggests that a detailed temporal analysis of electrophysiological responses is warranted to better identify the time window at which circadian rhythms are most receptive to light-induced phase shifting.
| Item Type: | Journal Article | ||||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
| SWORD Depositor: | Library Publications Router | ||||||
| Journal or Publication Title: | Journal of Biological Rhythms | ||||||
| Publisher: | Sage Publications Ltd. | ||||||
| ISSN: | 0748-7304 | ||||||
| Official Date: | 1 December 2017 | ||||||
| Dates: |
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| Volume: | 32 | ||||||
| Number: | 6 | ||||||
| Page Range: | pp. 583-592 | ||||||
| DOI: | 10.1177/0748730417735397 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||
| Date of first compliant deposit: | 25 September 2018 |
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