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Microfluidics for protein biophysics
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Charmet, Jérôme, Arosio, Paolo and Knowles, P. J. Knowles (2018) Microfluidics for protein biophysics. Journal of Molecular Biology, 430 (5). pp. 565-580. doi:10.1016/j.jmb.2017.12.015 ISSN 0022-2836.
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Official URL: https://doi.org/10.1016/j.jmb.2017.12.015
Abstract
Microfluidics has the potential to transform experimental approaches across the life sciences. In this review, we discuss recent advances enabled by the development and application of microfluidic approaches to protein biophysics. We focus on areas where key fundamental features of microfluidics open up new possibilities and present advantages beyond low volumes and short time-scale analysis, conventionally provided by microfluidics. We discuss the two most commonly used forms of microfluidic technology, single-phase laminar flow and multiphase microfluidics. We explore how the understanding and control of the characteristic physical features of the microfluidic regime, the integration of microfluidics with orthogonal systems and the generation of well-defined microenvironments can be used to develop novel devices and methods in protein biophysics for sample manipulation, functional and structural studies, detection and material processing.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) | ||||||||
| Journal or Publication Title: | Journal of Molecular Biology | ||||||||
| Publisher: | Academic Press | ||||||||
| ISSN: | 0022-2836 | ||||||||
| Official Date: | 2 February 2018 | ||||||||
| Dates: |
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| Volume: | 430 | ||||||||
| Number: | 5 | ||||||||
| Page Range: | pp. 565-580 | ||||||||
| DOI: | 10.1016/j.jmb.2017.12.015 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Date of first compliant deposit: | 22 December 2017 | ||||||||
| Date of first compliant Open Access: | 20 March 2018 | ||||||||
| Related URLs: |
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