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Utility values for childhood obesity interventions : a systematic review and meta-analysis of the evidence for use in economic evaluation
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Brown, V., Tan, E. H., Hayes, A. J. (Anthony J.), Petrou, Stavros and Moodie, M. L. (2018) Utility values for childhood obesity interventions : a systematic review and meta-analysis of the evidence for use in economic evaluation. Obesity Reviews, 19 (7). pp. 905-916. doi:10.1111/obr.12672
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WRAP-Utility-values-childhood-obesity-interventions-evidence-Petrou-2017.pdf - Accepted Version - Requires a PDF viewer. Download (1038Kb) | Preview |
Official URL: http://doi.org/10.1111/obr.12672
Abstract
Rigorous estimates of preference-based utilities are important inputs into economic evaluations of childhood obesity interventions, yet no published review currently exists examining utility by weight status in paediatric populations. A comprehensive systematic literature review and meta-analysis was therefore undertaken, pooling data on preference-based health state utilities by weight status in children using a random-effects model. Tests for heterogeneity were performed, and publication bias was assessed. Of 3,434 potentially relevant studies identified, 11 met our eligibility criteria. Estimates of Cohen's d statistic suggested a small effect of weight status on preference-based utilities. Mean utility values were estimated as 0.85 (95% uncertainty interval [UI] 0.84–0.87), 0.83 (95% UI 0.81–0.85), 0.82 (95% UI 0.79–0.84) and 0.83 (95% UI 0.80–0.86) for healthy weight, overweight, obese and overweight/obese states, respectively. Meta-analysis of studies reporting utility values for both healthy weight and overweight/obese participants found a statistically significant weighted mean difference (0.015, 95% UI 0.003–0.026). A small but statistically significant difference was also estimated between healthy weight and overweight participants (0.011, 95% UI 0.004–0.018). Study findings suggest that paediatric-specific benefits of obesity interventions may not be well reflected by available utility measures, potentially underestimating cost-effectiveness if weight loss in childhood/adolescence improves health or well-being.
| Item Type: | Journal Article | ||||||||
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| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | Obesity Reviews | ||||||||
| Publisher: | Wiley-Blackwell Publishing Ltd. | ||||||||
| ISSN: | 1467-7881 | ||||||||
| Official Date: | July 2018 | ||||||||
| Dates: |
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| Volume: | 19 | ||||||||
| Number: | 7 | ||||||||
| Page Range: | pp. 905-916 | ||||||||
| DOI: | 10.1111/obr.12672 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access |
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